摘要
目的优选舒胸舌下片辅料配方和舌下黏膜促透剂配方。方法按正交实验设计,优选乳糖、甘露醇、微晶纤维素最佳比例;采用Frank扩散池进行体外扩散实验,HPLC测定人参皂苷Rg1的累积透膜量,按星点设计-效应面法设计实验,优选氮酮、油酸和薄荷醇的最佳比例。结果舌下片最佳制备工艺为药材提取物-〔乳糖-甘露醇(1∶9)〕-微晶纤维素为6∶8∶0.5加2%的氮酮、2%的油酸、5%薄荷醇复合促透剂制片。结论舒胸舌下片辅料配方能保证片剂的性状参数,复合黏膜促透作用稳定。
Objective prepare shuxiong sublingual tablet and study the sublingual mucosa permeation enhancer .Methods The sublingual tablets was made by lactose ,mannitol and MCC orthogonal test .According to central composite design-response surface methodolo-gy, drug vitro permeation tests were performed in Frank diffusion cell .The accumulation transmittance of Ginsenoside Rg 1 concentration in samples was determined by HPLC.Results The sublingual tablet was made by dry extract powders:lactose and mannitol(1:9):MCC=6:8:0.5.The best complex accelerators were composed of 2 percent Azone, 2 percent Oleic acid and 5 percent menthol.Conclusions Shux-iong sublingual tablet preparation process is reasonable and composite membrane agent penetration effect is stable .
出处
《中国老年学杂志》
CAS
CSCD
北大核心
2014年第21期6096-6100,共5页
Chinese Journal of Gerontology
基金
国家自然科学基金项目(No.81072120)
关键词
舒胸舌下片
人参皂苷RG1
复合透膜剂
星点设计-效应面法
Shuxiong sublingual tablet
Ginsenoside Rg1
Complex accelerators
Central composite design-response surface methodology
