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晚期非小细胞肺癌患者表皮生长因子受体突变的检测 被引量:3

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摘要 目的检测晚期非小细胞肺癌(NSCLC)患者表皮生长因子受体(EGFR)的基因突变情况。方法收集胸恶性腔积液脱落细胞、转移性淋巴结和气管镜活检组织标本,采用突变特异性扩增系统(ARMS)法进行EGFR突变检测。结果在34例NSCLC患者标本中发现EGFR突变19例(56%),包括15例19外显子缺失,2例21外显子点突变,2例外显子19、21双突变。EGFR突变更多的出现非吸烟、肺腺癌患者中(P<0.05),与年龄、性别、身体状态评分、标本类型无明显相关(P>0.05)。EGFR突变阳性和突变阴性组患者在组织标本和细胞学标本中DNA浓度差异无统计学意义(P>0.05)。在19例接受氨酸蛋白激酶小分子抑制剂(TKIs)治疗的患者中EGFR突变阳性较突变野生型患者临床获益更多(P<0.05)。结论 ARMS法检测胸恶性腔积液脱落细胞、转移性淋巴结和气管镜活检组织标本进行EGFR基因突变检测,其结果可靠、实用,为晚期NSCLC患者在无法获得足量手术切除肿瘤组织标本的情况下实行TKIs治疗提供预测依据。
出处 《中国老年学杂志》 CAS CSCD 北大核心 2015年第3期657-658,659,共3页 Chinese Journal of Gerontology
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