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老年颅脑损伤患者CT图像评分与血清中髓鞘碱性蛋白、神经元特异性烯醇化酶和S100B蛋白表达的关系 被引量:12

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摘要 目的观察颅脑损伤老年患者头颅CT图像评分与血清中髓鞘碱性蛋白(MBP)、神经元特异性烯醇化酶(NSE)和S100B蛋白(S100B)的关联性。方法 98例颅脑损伤的老年患者,均于伤后24 h内行头颅CT检查,计量CT图像评分,同时检测伤后24 h内空腹静脉血中MBP、NSE和S100B的含量。结果不同CT图像评分分组MBP、NSE和S100B表达差异显著,CT图像评分与格拉斯哥昏迷评分(GCS)具有负相关性,CT图像计分与MBP、NSE和S100B的表达均具有正相关性。结论老年人颅脑损伤后CT图像评分与MBP、NSE和S100B具有一定的相关性,因此早期积极检测MBP、NSE和S100B表达对诊断及治疗可能有重要价值。
出处 《中国老年学杂志》 CAS CSCD 北大核心 2015年第8期2124-2126,共3页 Chinese Journal of Gerontology
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参考文献20

  • 1Costine Beth A,Quebeda-Clerkin Patricia B,Dodge Carter P,Harris Brent T,Hillier Simon C,Duhaime Ann-Christine.Neuron-Specific Enolase, but Not S100B or Myelin Basic Protein, Increases in Peripheral Blood Corresponding to Lesion Volume after Cortical Impact in Piglets. Journal de Neuroradiologie . 2012
  • 2Wang Wenlan,Li Ya,Ren Jie,Xia Feng,Li Jinsheng,Zhang Zuoming.Hydrogen rich saline reduces immune-mediated brain injury in rats with acute carbon monoxide poisoning. Neurological Research . 2012
  • 3Papa L,Ramia MM,Kelly JM.Systematic review of clinicalresearch on biomarkers for pediatric traumatic brain injury. Journal of Neurotrauma . 2013
  • 4Geyer Christian,Ulrich Anett,Gr?fe Gerd,Stach Barbara,Till Holger.Diagnostic value of S100B and neuron-specific enolase in mild pediatric traumatic brain injury. Journal of neurosurgery. Pediatrics . 2009
  • 5Neuron-Specific Enolase, S100B, and Glial Fibrillary Acidic Protein Levels as Outcome Predictors in Patients With Severe Traumatic Brain Injury[J]. Neurosurgery . 2011 (6)
  • 6Wolf H,Frantal S,Pajenda GS,et al.Predictive value of neuromarkers supported by a set of clinical criteria in patients with mild traumatic brain injury:S100B protein and neuron-specific enolase on trial:clinical article. Journal of Neurosurgery . 2013
  • 7An N. Massaro,Taeun Chang,Nadja Kadom,Tammy Tsuchida,Joseph Scafidi,Penny Glass,Robert McCarter,Stephen Baumgart,Gilbert Vezina,Karin B. Nelson.Biomarkers of Brain Injury in Neonatal Encephalopathy Treated with Hypothermia[J]. The Journal of Pediatrics . 2012 (3)
  • 8The usefulness of S100B, NSE, GFAP, NF-H, secretagogin and Hsp70 as a predictive biomarker of outcome in children with traumatic brain injury[J]. Acta Neurochirurgica . 2012 (1)
  • 9Berger Rachel Pardes,Adelson P David,Richichi Rudolph,Kochanek Patrick M.Serum biomarkers after traumatic and hypoxemic brain injuries: insight into the biochemical response of the pediatric brain to inflicted brain injury. Developmental Neuropsychology . 2006
  • 10Hergenroeder Georgene W,Redell John B,Moore Anthony N,Dash Pramod K.Biomarkers in the clinical diagnosis and management of traumatic brain injury. Molecular diagnosis & therapy . 2008

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