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N-末端脑钠肽前体对ICU老年危重病患者预后的预测价值

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摘要 目的评价ICU老年危重病人N-末端脑钠肽前体(NT-pro BNP)水平与疾病预后的关系。方法选择142例年龄>60岁患者,在患者入ICU的24 h内检测血浆NT-pro BNP浓度,同时记录相关生理指标,随访患者入ICU 28 d内的生存状况,并根据以上数据绘制受试者工作特征(ROC)曲线,使用Kaplan-Meier生存曲线比较不同水平NT-pro BNP浓度患者生存情况。结果 142例老年危重症患者中,存活组和死亡组NT-pro BNP水平有显著差异(P<0.05);NT-pro BNP≥1 172.5 ng/L的预测价值最佳;NT-pro BNP≥1 172.5 ng/L与<1 172.5 ng/L患者组相比,氧和指数、肌酐值、机械通气时间以及死亡率以及累积生存时间均有统计学差异(P<0.05)。结论入ICU时NT-pro BNP水平对老年危重症患者疾病的预后有预测价值,≥1 172.5 ng/L提示预后不佳。
出处 《中国老年学杂志》 CAS CSCD 北大核心 2015年第11期3049-3051,共3页 Chinese Journal of Gerontology
基金 十二五国家科技支撑计划子课题(2012BA137805)
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