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阿伐他汀对ApoE基因敲除小鼠海马和大脑皮质HDAC4和pCREB表达的影响 被引量：1

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摘要 目的探讨阿伐他汀对高脂血症模型小鼠脑组织组蛋白去乙酰酶(HDAC4)和p CREB表达的影响。方法将16只雄性Apo E基因敲除小鼠随机分成两组,一组正常饮食,一组在正常饮食同时给予阿伐他汀灌胃。实验结束后称重测血脂,取脑组织固定,石蜡切片后进行HE和免疫组化染色。结果阿伐他汀治疗组小鼠海马和大脑皮质HDAC4表达水平显著下降(P<0.05),而p CREB表达水平显著增加(P<0.05)。结论提示HDAC4和转录因子p CREB在阿伐他汀改善高脂血症引起的脑神经退行性疾病可能具有重要作用。
作者 李报 黄大可 桂丽 汪渊 芦宝静 贾雪梅
机构地区 安徽医科大学基础医学院
出处 《中国老年学杂志》 CAS CSCD 北大核心 2015年第13期3496-3497,共2页 Chinese Journal of Gerontology
基金 国家自然科学基金(30570750) 安徽省教育厅自然科学基金(KJ2012A164)
关键词 阿伐他汀 APO E基因敲除 组蛋白去乙酰化酶 环磷腺苷效应元件结合蛋白
分类号 R965 [医药卫生—药理学]
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参考文献10

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二级参考文献15

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中国老年学杂志
2015年 第13期

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