摘要
目的分析济宁医学院附属医院甲状腺疾病手术患者构成的变化,探讨甲状腺癌病理学特点,寻找甲状腺疾病谱的变迁特点。方法采用描述性研究,回顾性收集2008年1月至2014年12月7年间行甲状腺手术并取得病理诊断的患者的病案资料,用SPSS 19.0统计软件分析比较不同特征人群、不同年份甲状腺疾病和甲状腺癌构成比变化。结果 (1)7年间甲状腺疾病手术患者明显增加,甲状腺癌与结节性甲状腺肿的增长速度最为明显(46.6%vs.12.8%)。(2)甲状腺癌的构成比呈升高趋势,从2008年的13.6%逐渐升至2014年的39.6%;结节性甲状腺肿构成比仍处于首位,但呈缓慢下降趋势。(3)乳头状癌(PTC)构成比维持在相对稳定的高水平,微小乳头状癌构成比呈上升趋势,2008年微小乳头状癌占甲状腺癌比例仅为22.8%,而2014年达58.0%。(4)高碘地区与非高碘地区甲状腺疾病构成比差异有统计学意义(χ2=70.61,P<0.01),甲状腺癌的病理类型构成差异无统计学意义(χ2=0.28,P=0.60),高碘地区乳头状癌比例高于非高碘地区(96.3%vs.95.7%)。结论甲状腺住院手术患者病种及甲状腺癌病理类型构成发生了变化;甲状腺癌的构成比呈升高趋势,尤其是微小乳头状癌。高碘地区与非高碘地区甲状腺癌的病理类型构成差异无统计学意义,考虑与在高水碘地区供应无碘食盐和降碘改水的防治策略的实施有关。
Objective To analyze the changes in the constituent ratio of patients received surgical therapy from Affiliated Hospital of Jining Medical University, to explore the pathological characteristics of thyroid cancer, and to find the changes in disease spectrum. Methods Using descriptive study, a retrospective analysis of the clinical data of patients received surgical therapy with pathologically confirmed findings from 2008 January to December 2014. The constituent ratio of thyroid diseases and thyroid tumor among different population groups in different years were analyzed with SPSS 19.0 statistical software. Results(1) The number of patients with thyroid disease admitted hospital had significantly increased in the past 7 years, particularly those with nodular goiter or thyroid cancer, the malignant tumor growing faster than nodular goiter(46.6% vs. 12.8%).(2) The composition ratio of thyroid cancer increased from 13.6% in 2008 to 39.6% in 2014; the overall proportion of nodular goiter in the leading position, but decreased slowly.(3) The composition ratio of papillary thyroid carcinoma was maintained at a relatively high level, the composition ratio of papillary thyroid micro-carcinoma increased significantly, which increased from only 22.8% in 2008 to 58.0% in 2014.(4) There was statistically significant difference of constitution of thyroid disease between high iodine area and non high iodine area(χ2=70.61, P<0.01), but the pathological type's constitution of thyroid cancer had no statistical difference. The proportion of papillary carcinoma in high iodine area was higher than that in non high iodine region(96.3% vs. 95.7%). Conclusions Thyroid disease and tumor pathological types had dramatically changed in hospitalized patients. The occurrence of thyroid carcinoma, especially papillary micro-carcinoma has been increasing. There was no statistical difference in the pathological types of thyroid carcinoma in the areas of high iodine and non-high iodine, because we supply without iodine salt and implement the control strategy of iodine water reduction in high iodine area.
出处
《中华临床医师杂志（电子版）》
CAS
2017年第1期77-82,共6页
Chinese Journal of Clinicians(Electronic Edition)
基金
济宁医学院附属医院"苗圃"科研计划项目(MP-2015-008)
济宁医学院2013年校级科研项目资助(JY2013KJ045)
关键词
甲状腺疾病
构成比
甲状腺乳头状癌
微小癌
水碘
Thyroid diseases
Constituent ratio
Papillary thyroid carcinoma
Micro-carcinoma
Water iodine
