摘要
阻塞性黄疸是由于肝外胆管或肝内胆管阻塞所致的黄疸,前者称为肝外阻塞性黄疸,后者称为肝内阻塞性黄疸。肠道菌群是人体最重要、最复杂的微生态系统,在维持宿主的正常生理状态、抵抗致病菌侵袭方面都具有极其重要的作用。阻塞性黄疸可对肠道微生态环境产生显著影响,导致肠道黏膜机械屏障及免疫屏障功能受损,引起肠道菌群失调,继发地诱发急慢性腹泻、多种生理功能障碍,严重的可发生休克甚至死亡。本文对近年来有关阻塞性黄疸与肠道菌群相互影响的研究内容进行综述,为阻塞性黄疸的诊治、减少并发症、降低致死率提供参考。
Obstructive jaundice is the clinical pathological state which mainly refers to the stained yellow caused by entire biliary high pressure and conjugate bilirubin flows back into blood induced by bile duct ligation.The intestinal flora is the most important and complex microecosystem in human body and plays an extremely important role in maintaining the normal physiological state and preventing the pathogenic bacteria from invading the host.Biliary obstruction and cholestasis may significantly affect the intestinal microecological environment,and damage the intestinal mucosal mechanism and immune barrier,which may lead to dysbacteriosis.Then may it induce acute and chronic diarrhea,intestinal mucosal dysfunction,severe shock or even death.The probiotics,Chinese herbals,and antibiotics were used to regulate the intestinal microecological structure in biliary drainage to relieve obstruction,and to restore the dynamic equilibrium to reduce the complications and mortality.
作者
叶方
梅琼
YE Fang;MEI Qiong(Department of Pharmacy,Taihe Hospital Affiliated with Hubei University of Medicine,Shiyan Hubei 442000;Hubei University of Medicine,Shiyan Hubei 442000)
出处
《中南药学》
CAS
2019年第5期705-709,共5页
Central South Pharmacy
关键词
阻塞性黄疸
肠道菌群
干预措施
obstructive jaundice
intestinal flora
intervention
