摘要
目的 探讨复方银杏滴丸 (CO -GBE)抗血栓形成及抑制血小板聚集的作用。方法 ①制造大鼠动静脉旁路血栓形成模型 ,测定血栓湿重及干重 ;②分别采用胶原、PAF、ADP诱导豚鼠血小板聚集 ,测定血小板在不同时间点的聚集率以及最大聚集率。结果 复方银杏滴丸 4 0、2 0、10mg/kg均可以不同程度地抑制大鼠动静脉旁路血栓形成 ,减轻血栓干重及湿重 (P <0 .0 5 ,P <0 .0 1) ;抑制不同诱导剂诱导的豚鼠血小板在不同时间点的聚集 ,降低其最大聚集率。结论 复方银杏滴丸可明显抗血栓形成 。
Objective To investigate the effects of Compound Gingko Guttate Pills (CGGPs) against thrombosis and platelet aggregation. Methods Rats were used to establish the model of artery vein bypass thrombosis and the thrombus weight (either wet or dry) was measured. Collagen, platelet active factor and adenosine diphosphate were used to induce platelet aggregation in the guinea pigs and the ratio of platelet aggregation in different times and the maximum ratio of platelet aggregation were detected. Results All CGGPs doses (40 mg/kg, 20 mg/kg, 10 mg/kg) could inhibit artery vein bypass thrombosis in different degrees, reduce thrombus weight (either wet or dry, P<0 05, P <0 01) in rats; and inhibit platelet aggregation with different revulsant in different times, and reduce the maximum ratio of platelet aggregation in guinea pigs. Conclusion CGGPs exert remarkable effects against thrombosis and possess strong effects against platelet aggregation in a large scope.
出处
《北京中医药大学学报》
CAS
CSCD
北大核心
2004年第1期42-44,共3页
Journal of Beijing University of Traditional Chinese Medicine
关键词
复方银杏滴丸
血栓形成
血小板聚集
Compound Gingko Guttate Pills
Thrombosis
Platelet Aggregation
