摘要
目的:观察加味参苓白术散联合甲状腺素片治疗桥本氏甲状腺炎(Hashimoto’s thyroiditis,HT)的临床疗效。方法:68例HT患者根据随机数字表法,随机分为治疗组与对照组,每组34例。对照组单独采用甲状腺素片治疗临床方案,治疗组在对照组治疗的基础上,给予加味参苓白术散汤剂治疗。观察2组HT患者治疗前后游离三碘甲状腺原氨酸(free triiodothyronine,FT_3),游离甲状腺素(free Thyroxine,FT4),促甲状腺激素(thyroid stimulating hormone,TSH),免疫学指标血清甲状腺过氧化物酶抗体(thyroidperoxidase antibody,TPOAb),甲状腺球蛋白抗体(thyroglobulin antibody,Tg Ab),中医证候积分的变化,并观察中药组方的安全性。结果:经过3个月的治疗后,治疗组有效率(91. 2%)明显高于对照组(70. 6%)(P <0. 05);两组中医证候积分经3个月治疗后较本组治疗前明显下降(P <0. 05),治疗组中医证候积分较对照组下降更明显(P <0. 05)。两组FT_3,FT4水平经3个月治疗后较本组治疗前显著上升(P <0. 01),治疗组上升趋势显著优于对照组(P <0. 01);两组TSH,Tg Ab,TPOAb经3个月治疗后较本组治疗前均明显下降(P <0. 05),且治疗组下降趋势更明显(P <0. 05);在治疗过程中未见任何不良反应发生。结论:加味参苓白术散联合甲状腺素片治疗HT,相较于单纯甲状腺素片临床效果显著,值得进一步临床和实验研究。
Objective:To observe the clinical efficacy of modified Shenling Baizhu San combined with thyroxine tablets in the treatment of Hashimoto’s thyroiditis(HT).Method:The 68 patients with HT were randomly divided into treatment group and control group,with 34 patients in each group.Control group was treated with thyroxine tablets alone,while treatment group was treated with modified Shenling Baizhu San in addition to the therapy of control group.Free triiodothyronine(FT3),free Thyroxine(FT4),thyroid stimulating hormone(TSH),serum thyroid peroxidase antibody(TPOAb)and thyroglobulin were observed before and after treatment in the two groups of HT patients.The changes of thyroglobulin antibody(TgAb)and traditional Chinese medicine(TCM)syndrome score,and the safety of TCM prescription were observed.Result:After 3 months of treatment,the effective rate of treatment group was 91.2%,which was significantly higher than 70.6%of control group,with statistically significant difference(P<0.05);after 3 months of treatment,the scores of TCM syndromes in two groups were significantly lower than those before treatment(P<0.05),and the scores of TCM syndromes in treatment group were significantly lower than those in control group(P<0.05).FT3 and FT4 in treatment group and control group increased significantly after 3 months of treatment(P<0.01),but treatment group increased more significantly than control group(P<0.01);TSH,Tg Ab and TPOAb in treatment group and control group decreased significantly after 3 months of treatment(P<0.05),and treatment group decreased more significantly than before treatment(P<0.05),with no adverse reaction during the treatment.Conclusion:Modified Shenling Baizhu San combined with thyroxine tablets in the treatment of HT is more effective than simple thyroxine tablets,which is worthy of further clinical and experimental study.
作者
陈晓明
蔡美香
庄丽明
骆良钦
蔡向阳
CHEN Xiao-ming;CAI Mei-xiang;ZHUANG Li-ming;LUO Liang-qin;CAI Xiang-yang(The Second Affiliated Hospital of Fujian Medical University,Quanzhou 362000,China;Quanzhou Third Hospital,Quanzhou 362000,China)
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2019年第10期15-19,共5页
Chinese Journal of Experimental Traditional Medical Formulae
基金
上海市高级中西医结合人才培养项目(ZYSNXD012-RC-ZXY013)
关键词
参苓白术散
桥本氏甲状腺炎
中西医结合
临床观察
不良反应
Shenling Baizhu San
Hashimoto’s thyroiditis(HT)
integrated traditional Chinese and western medicine
clinical observation
adverse reactions
