摘要
表界面作为两相之间的过渡区域,属于物理化学范畴,目前在材料等科学领域广泛应用。同样,在药学研究中该性质也起着重要作用。药物制剂研究过程中所涉及的界面层离不开气-液-固之间二相或三相的相互作用,界面作用会影响制剂最终的成型性以及药物在人体内的溶出、吸收等。笔者通过对比表面积、表界面张力、表面吉布斯自由能等表界面特性的概述以及润湿、增溶、乳化等界面现象在药学研究中应用的分析,从药物制剂的过程控制及制剂产品的有效性等角度阐述表界面特性在药物制剂领域的重要作用。提示表界面特性作为药物的关键物理性质之一加以重视并应用到药学研究中是必要的。
The surface and interface,as the transition region between two phases,belongs to the category of physical chemistry.At present,it is widely used in materials and other scientific fields.Meanwhile,this property also plays an important role in pharmaceutical research.The interface layer involved in the progress of pharmaceutical preparations is connected with the two-phase or three-phase between gas,liquid and solid closely.The interface effect will affect the final shaping of pharmaceutical preparations and the dissolution and absorption of drugs in the human body.In this paper,the surface and interface characteristics(specific surface area,surfacial and interfacial tension and surface Gibbs free energy)were compared,and the application of interface phenomena(wetting,solubilization and emulsification)in pharmaceutical research were introduced.From the points of view of the progress control of pharmaceutical preparations and the effectiveness of their products,the article expounds the important role of properties of surface and interface in the field of pharmaceutical preparations.Therefore,it is necessary to pay attention to the properties of surface and interface,one of the key physical properties of drugs,and to apply them in the pharmaceutical research.
作者
李佳璇
施晓虹
赵立杰
冯怡
杜若飞
洪燕龙
王优杰
LI Jia-xuan;SHI Xiao-hong;ZHAO Li-jie;FENG Yi;DU Ruo-fei;HONG Yan-long;WANG You-jie(Engineering Research Center of Modern Preparation of Traditional Chinese Medicine(TCM),Ministry of Education,Innovation Research Institute of TCM,Shanghai Innovation Center of TCM Health Service,Shanghai University of TCM,Shanghai 201203,China)
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2019年第11期216-223,共8页
Chinese Journal of Experimental Traditional Medical Formulae
基金
国家自然科学基金项目(81503263)
上海市科学技术委员会项目(16401902300)
上海市卫计委中医药科技创新项目(ZYKC201603003)
关键词
药物制剂
比表面积
表面张力
表面自由能
界面作用
乳化
增溶
pharmaceutic preparations
specific surface area
surface tension
surface free energy
interfacial action
emulsion
solubilization
