摘要
目的:海龙是我国重要的动物药材,用药历史悠久,基原众多。该研究的目的是澄清海龙尤其是尖海龙的物种基原,为海龙类药材的鉴定和质量标准提供依据。方法:对历代海龙本草文字记载、图片和照片进行考证,结合形态和DNA序列分析,对中国科学院动物研究所、中国食品药品检定研究院等标本馆馆藏动物标本、中药标本及我国主要中药市场市售样本进行药源调查,推断本草及2015年版《中国药典》中海龙的物种基原。结果:从我国7个省份的药店或药材经销商处收集到标为'尖海龙'的36批药材,以及中药标本馆中历年来存留的8批'尖海龙'样品的形态与DNA均符合舒氏海龙Syngnathus schlegeli (Kaup,1856)。2015年版《中国药典》收载海龙性状描述也为舒氏海龙鉴别特征。中国的尖海龙S.acus可能是舒氏海龙S.schlegeli的错误鉴定。结论:2015年版《中国药典》中海龙的基原应修订为刁海龙Solegnathus hardwickii(Gray,1830),拟海龙Syngnathoides biaculeatus (Bloch,1785)或舒氏海龙S.schlegeli (Kaup,1856)的干燥品。2015年版《中国药典》收载的尖海龙S.acus应修订为舒氏海龙S.schlegeli。并建议增加鉴别方法,完善海龙质量控制标准。
Objective:Syngnathus has long been used as an important traditional animal medicine in China,but many syngnathus-like animals also used as Hailong in herbal markets.This study aims to define the zoological origin of Syngnathus in China Pharmacopoeia.Method:Herbalogical records,particularly pictures and photographs of ancient literatures,Syngnathus specimens in museum were stidued to determine the zoological origin of Syngnathus in Chinese herbal medical classics and China Pharmacopoeia.Result:Based on the morphological and DNA sequencing,all the commercial'S.acus'originated from Syngnathus schlegeli(Kaup,1856).Feature description of'S.acus'in China Pharmacopoeia also conformed to S.schlegeli.S.acus in China may be a misidentification of S.schlegeli.Conclusion:Syngnathus in China Pharmacopoeia originates from Solegnathus hardwickii(Gray,1830),Syngnathoides biaculeatus(Bloch,1785)or Syngnathus schlegeli(Kaup,1856).It is suggested to add identification methods of'Hailong',especially molecular identification methods in China Pharmacopoeia,in order to improve quality control standards of Syngnathus.
作者
蒋超
袁媛
李军德
金艳
JIANG Chao;YUAN Yuan;LI Jun-de;JIN Yan(State Key Laboratory Breeding Base of Dao-di Herbs,National Resource Center for Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing 100700,China)
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2019年第17期104-112,共9页
Chinese Journal of Experimental Traditional Medical Formulae
基金
国家药典委员会“《中国药典》药品标准提高项目”(2016-8)
中央本级重大增减支项目(2060302)
中央级公益性科研院所基本科研业务费专项(ZZ10-008)
关键词
海龙
基原
《中国药典》
尖海龙
舒氏海龙
Syngnathus
zoological origin
China Pharmacopoeia
Syngnathus acus Linnaeus
Syngnathus schlegeli Kaup
