摘要
胆囊癌恶性程度高,有效的治疗药物少。中药因其多靶点、多环节、多途径且毒副作用较小的优势受到诸多研究者关注。近年来,中药有效成分在胆囊癌基础研究方面取得了一定的成果,相关的实验研究已走向细胞、分子及基因水平,实验研究的机制可概括为抑制肿瘤细胞增殖、诱导肿瘤细胞凋亡、转移和迁徙、影响信号传导通路、增强化疗药物的敏感性以及抑制肿瘤血管生成等方面。现有的实验研究表明中药有效成分抗胆囊癌具有一定的疗效,但依然存在诸多问题,如中药有效成分虽然显示出抗肿瘤活性,但具体化学分子结构不甚明确;目前大多数研究集中在体外细胞实验水平,动物体内实验研究较少,未来需要更深入的研究;当前,中药抗胆囊癌的机制大部分为经典的信号通路,下一步可寻找新的信号通路及新的作用靶点。另外,在以后的研究中,可增加在中医理论指导下中药复方的研究,进一步发挥传统中医药抗肿瘤的优势。该文根据现有的实验研究作一综述,有利于研究者了解中药有效成分在胆囊癌实验研究的现状以便对其进行更深入的研究,进而可以为临床治疗提供理论依据。
Allbladder cancer is highly malignant and has few effective therapeutic drugs.Traditional Chinese medicine(TCM)has attracted the attention from researchers because of its multi-target,multi-link,multichannel and less toxic side effect.In recent years,the basic studies of gallbladder cancer have made certain achievements in active components of TCM.Relevant experimental studies have extended to the lever of cells,molecules and genes.The main mechanism of experimental research include inhibiting tumor cell proliferation,inducing tumor cell apoptosis,inhibiting cell metastasis,inhibiting cell migration,influencing signal transduction pathway,enhancing sensitivity of chemotherapeutic drugs,and inhibiting tumor angiogenesis.The existing experimental studies have showed that active components of TCM have certain curative effect on gallbladder cancer,but with many problems.For example,although the extract of active components of TCM shows an anti-tumor activity,the specific composition and chemical molecular structure are still unclear.Most studies focus on the level of in vitro cell experiments,but only a few in vivo experimental studies have been carried out in animals.Therefore,more in-depth studies need to be carried out in the future.Currently,most of the mechanisms of antigallbladder cancer of active components of TCM are classical signaling pathways.The next step is to find new signaling pathways and new targets.In addition,under the guidance of TCM theory,the future studies of TCM compound can bring advantages of TCM against tumor into full play.The experimental study on the mechanism of action of active components of TCM in the treatment of gallbladder cancer is summarized as follows,which is helpful for researchers to understand the current experimental studies on active components of TCM in gallbladder cancer,in order to conduct more in-depth studies.Basic experimental studies on gallbladder cancer can provide theoretical basis for clinical treatment.
作者
朱治法
苏丽
夏霖
张兴龙
张梅
李平
ZHU Zhi-fa;SU Li;XIA Lin;ZHANG Xing-long;ZHANG Mei;LI Ping(The First Affiliated Hospital of Anhui Medical University,Hefei 230022,China;Anhui University of Chinese Medicine,Hefei 230038,China)
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2019年第23期222-228,共7页
Chinese Journal of Experimental Traditional Medical Formulae
基金
国家自然科学基金面上项目(81673908)
关键词
胆囊癌
中药有效成分
实验
机制
gallbladder cancer
active components of traditional Chinese medicine(TCM)
experimental study
mechanism
