摘要
目的研究宫颈病变和宫颈癌患者高危型HPV感染情况、年龄分布及亚型分布,分析高危型HPV感染与宫颈癌前病变及宫颈癌的相关性,为宫颈癌的预防筛查工作提供实验依据。方法按宫颈病变程度将313名宫颈病变患者分为CIN I、CINII、CINIII、宫颈癌4组,检测患者高危型HPV-DNA感染情况。结果 CINI组高危型HPVDNA的阳性率为16.67%,CINII组阳性率为60.38%,CINIII组阳性率为69.74%,宫颈癌组的阳性率最高,为75.42%;癌前病变(CINII-CINIII)和宫颈癌组均在41-60岁年龄区间感染率最高;癌前病变组中感染率较高的型别为HPV16(31.01%)、HPV58(14.73%)、HPV52(10.85%);宫颈癌组中感染率较高的型别依次为HPV16(47.46%),HPV18(16.69%),HPV58(11.86%),HPV52(5.93%)。结论随着宫颈病变的加重,阳性感染率也呈递增趋势;癌前病变和宫颈癌组的年龄感染高峰为41-60岁;HPV16、58、52是宫颈癌前病变的主要感染亚型;HPV16、18、58、52是宫颈癌的主要感染亚型。
Objective Research on high-risk human papillomavirus(HPV)infection in patients with cervical disease and cervical cancer,age distribution and strain distribution,analysis the correlation of high-risk HPV infection and cervical cancer disease,to provide theoretical basis for future work of cervical cancer prevention and screening.Methods According to the degree of cervical lesions,313 patients were divided into CIN I,CINⅡ,CINⅢ,and cerical cancer.Test the patients with high-risk HPV infection.Results CIN I group positive rate was 16.67%,CINⅡgroup positive rate was 60.38%,CINⅢgroup positive rate was 69.74%,Cervical cancer group has the highest positive rate is 75.42%;CINⅡgroup,CINⅢgroup and cervical cancer group had the highest infection rates in the age of 41-60.There are 12 kinds of HPV in cervical lesions group high-risk type is checked out,the higher infection rate of type in the order were HPV16(31.01%)、HPV58(14.73%)、HPV52(10.85%).There are 12 kinds of HPV in cervical cancer group high-risk type is checked out,the higher infection rate of type in the order were HPV16(47.46%)、HPV18(16.69%)、HPV58(11.86%)、HPV52(5.93%).Conclusion As the cervical lesion is aggravating,positive rate is also increasing trend;CINⅡ,CINⅢand cervical cancer had the peak age of 41-60 years old;H There are 12 kinds of HPV in cervical cancer group high-risk type is checked out,the higher infection rate of type in the order were HPV16(47.46%)、HPV18(16.69%)、HPV58(11.86%)、HPV52(5.93%).HPV16,58,52 are the major infection types of cervical precancerous lesions.HPV16,18,58,52 are the major infection types of cervical cancer.
作者
方莉
韩瑜
许媛
陈莹
郑阳
FANG Li;HAN Yu;XU Yuan(Clinical Laboratory,Affilated Hospital of North Sichuan Medical College,Nanchong 637000,China)
出处
《中国实验诊断学》
2019年第4期602-605,共4页
Chinese Journal of Laboratory Diagnosis
关键词
高危型HPV
宫颈病变
宫颈癌
High-risk human papillomavirus
Cervical precancerous lesions
Cervical cancer
