摘要
为提高氟苯尼考的溶解度和生物利用度,采用饱和水溶液法,以β-环糊精为包合材料制备包合物,通过正交试验对包合条件进行筛选,优选出的最佳包合工艺为包合温度70℃、包合时间5 h、搅拌速度300 r/min;并以扫描电镜、差示扫描量热分析等方法验证氟苯尼考β-环糊精包合物的形成;通过溶出速率法测定,氟苯尼考β-环糊精包合物比氟苯尼考对照品的水溶性提高了6.67倍。
In order to improve the solubility and bioavailability of florfenicol,β-cyclodextrin was used to prepare florfenicolβ-cyclodextrin inclusion complex with saturated aqueous solution method and orthogonal experiment was carried out to optimize the bonding process for inclusion.The results were follows:inclusion time was 5 h with stirring speed of 300 r/min at 70 ℃.In addition,scanning electron microscopy and differential scanning calorimetry analysis were used to verify the formation of florfenicol β-cyclodextrin inclusion complexes.Finally,the solubility of florfenicol β-cyclodextrin inclusion complexes was increased 6.67-fold compared to florfenicol by measuring the rate of dissolution.
出处
《中兽医医药杂志》
2015年第1期58-62,共5页
Journal of Traditional Chinese Veterinary Medicine
基金
自选课题
关键词
氟苯尼考
Β-环糊精
包合物
florfenicol
β-cyclodextrin
inclusion complex
