摘要
氧化应激为机体内活性氧的产生与抗氧化系统之间平衡失调,造成体内生物大分子(脂质、蛋白质以及DNA)损伤,导致细胞凋亡,从而诱发各种疾病的发生。抗氧化剂能有效调控机体的氧化应激与细胞凋亡,保障机体细胞内外环境的稳定和生理机能正常。氧化应激在高度集约化的现代养殖业中的危害已大量显现,减少或缓解畜禽的氧化应激已成为现代养殖业的重大课题。深入开展氧化应激与细胞凋亡以及新抗氧化剂的相关研究,对促进动物健康养殖和提高畜产品质量具有重要意义。笔者等在概述有关氧化应激与细胞凋亡的产生、反馈机制及其信号通道的基础上,综述了抗氧化剂应用的最新研究进展。
Oxidative stress is defined as imbalance between the production of reactive oxygen species(ROS) and antioxidant defenses in the organism. Excessive ROS results in oxidative stress and cell apoptosis that can be an important mediator of damage to cell structures and attacks cellular biomolecules such as lipid, protein and DNA, thereby leading to various kinds of diseases. Application of nutritional antioxidants in animals can protect intracellular and extracellular stabilization and physiological function by improving anti-oxidative function and inducing apoptosis. How to reduce or alleviate oxidative stress in livestock has become a major problem in high intensity farming systems because of a lot of hazards. It is of great importance studying on oxidative stress and apoptosis, as well as developing new antioxidants in promoting healthy animal farming and the enhancement of product quality of animals. In order to provide a reference for further study of oxidative stress and its mitigation measures, recent research progress of the production, mechanism and signal transduction pathway of oxidative stress and apoptosis as well as application of antioxidants in the animal were reviewed in this article.
出处
《中兽医医药杂志》
2015年第3期21-25,共5页
Journal of Traditional Chinese Veterinary Medicine
基金
国家自然科学基金资助项目(31201964)
教育部高校博士学科点专项基金教师类资助项目(20124320120011)
湖南省自然科学基金(2015JJ2077)
湖南省教育厅科学研究项目(12A066)
湖南农业大学公派出国科研启动基金(14RCPT12)
关键词
氧化应激
活性氧
细胞凋亡
oxidative stress
teactive oxygen species
apoptosis
