摘要
目的 观察不同剂量二异丙酚对自发性高血压大鼠 (SHR)血流动力学及其对血浆内皮素 (ET)、降钙素基因相关肽 (CGRP)、血管紧张素 (Ang )的影响 ,为临床高血压病人的麻醉结合其不同降压药物的使用、合理应用二异丙酚提供实验依据。 方法 1 2～ 1 4周雄性自发性 SHR2 4只随机分为 3组 (各 8只 ) :SA组 (生理盐水 ) ,SB组 (低剂量二异丙酚 )和 SC组 (高剂量二异丙酚 ) ;同龄雄性 WKY大鼠 2 4只随机分为 3组 (各 8只 ) :WA组 (生理盐水 ) ,WB组 (低剂量二异丙酚 )和 WC组 (高剂量二异丙酚 )。WA及 SA组 ,生理盐水 1 .2 m L/ kg1 5 s静注后持续注入生理盐水 1 2 m L· kg- 1 · h- 1 ;WB及 SB组静注二异丙酚 5 m g/ kg诱导麻醉后静脉持续注入二异丙酚 30 m g· kg- 1 · h- 1 30 m in;WC及 SC组静注二异丙酚 5 mg/ kg诱导麻醉后静脉持续注入二异丙酚 6 0 mg· kg- 1· h- 1 30 min维持 ,总容量均相同。记录未注药时、注药后 2 ,1 0 ,2 0 ,30 m in平均动脉压 (MAP)、心率 (HR)及呼吸频率 ,测定血浆 ET、CGRP、Ang 的含量。 结果 (1 )随着二异丙酚注入时间延长及剂量增加 ,SHR及 WKY大鼠均出现 MAP降低和 HR减慢 ;SHR出现改变的时间较 WKY早 ,下降幅度比 WKY大 ;
Objective To investigate the effects of propofol on hemodynamics a well as endothlin(ET), calcitonin gene|related peptide(CGRP) and angiotensin Ⅱ(AngⅡ) of plasma in spontaneously hypertensive rat(SHR). Methods 24 male SHR at age of 12~14 weeks were randomly allocated into 3 subgroups. Each group has eight rats(n=8): group SA:(control group, only injected with 0 9%NaCl); group SB(low dose propofol group); group SC(high dose propofol group). 24 male Wistar|Kyoto rats(WKY) at the same age were randomly allocated into 3 subgroups. Each group has eight rats(n=8): group WA:(control group, only injected with 0 9%NaCl); group WB(low dose propofol group); group WC(high dose propofol group). In groups SB and WB, after the infusion with propofol 5 mg/kg, 30 mg·kg+{-1}·h+{-1} propofol were administerted continuously; and in groups SC and WC, after the infusion with propofol 5 mg/kg, 60 mg·kg+{-1}·h+{-1} propofol were administered continuously. Mean blood pressre(MAP), and heart rate(HR) were monitored continously. After 30 min infusion, the concentrations of ET, AngⅡ and CGRP in plasma were determined. Results With the infusion of propofol, blood pressure decreased and heart rate slowed down significantly in both SHR and WKY groups, the changes in SHR were more obviously. In the time of baseline the concentrations of ET and AngⅡ in group SHR are higher than those in group WKY. The concentration of CGRP in group SHR was lower than that in group WKY. After infusion propofol, the levels of ET and AngⅡ of plasma decreased, CGRP increased. The changes in group SHR was obviously than WKY. Conclusion Propofol facilitates the release of CGRP, but inhibits the release of ET and AngⅡ. Propofol reduced blood pressure and slow down heart rate by changing the balance of ET AngⅡ and CGRP in dose and time dependent manners.
出处
《福建医科大学学报》
2004年第1期52-55,共4页
Journal of Fujian Medical University
基金
福建省卫生厅科研基金资助项目 ( 0 0 A0 81)
