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von Willebrand factor antigen as a therapeutic target of portal hypertension in cirrhosis 被引量：1

von Willebrand factor antigen as a therapeutic target of portal hypertension in cirrhosis
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摘要 Increased thrombotic potential within the liver sinusoids due to local endothelial production of von Willebrand factor antigen macromolecules could represent an additional therapeutic target of portal hypertension in patients with cirrhosis. In this case, anti-inflammatory and antithrombotic drugs could modulate portal pressure by preventing the formation of intrahepatic platelet-induced microthrombi. Increased thrombotic potential within the liver sinusoids due to local endothelial production of von Willebrand factor antigen macromolecules could represent an additional therapeutic target of portal hypertension in patients with cirrhosis. In this case, anti-inflammatory and antithrombotic drugs could modulate portal pressure by preventing the formation of intrahepatic platelet-induced microthrombi.
作者 Georgios N Kalambokis Gerasimos Baltayiannis Dimitrios Christodoulou
机构地区 [ Division of Gastroenterology
出处 《World Journal of Gastroenterology》 SCIE CAS 2016年第19期4786-4788,共3页 世界胃肠病学杂志（英文版）
关键词 von Willebrand factor ANTIGEN ENDOTHELIAL DYSFUNCTION Treatment PORTAL HYPERTENSION von Willebrand factor antigen Endothelial dysfunction Treatment Portal hypertension
分类号 R575.2 [医药卫生—消化系统]
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参考文献26

  • 1Juan Acevedo,Javier Fernández.New determinants of prognosis in bacterial infections in cirrhosis[J].World Journal of Gastroenterology,2014,20(23):7252-7259. 被引量：2
  • 2Hao Wu,Shiping Yan,Guangchuan Wang,Shaobo Cui,Chunqing Zhang,Qiang Zhu.??von Willebrand factor as a novel noninvasive predictor of portal hypertension and esophageal varices in hepatitis B patients with cirrhosis(J)Scandinavian Journal of Gastroenterology . 2015 (9)
  • 3Ashish Goel,Joshua E. Elias,Chundamannil E. Eapen,Banumathi Ramakrishna,Elwyn Elias.??Idiopathic Non-Cirrhotic Intrahepatic Portal Hypertension (NCIPH)—Newer Insights into Pathogenesis and Emerging Newer Treatment Options(J)Journal of Clinical and Experimental Hepatology . 2014 (3)
  • 4Gautam Mehta,Thierry Gustot,Rajeshwar P. Mookerjee,Juan Carlos Garcia-Pagan,Michael B. Fallon,Vijay H. Shah,Richard Moreau,Rajiv Jalan.??Inflammation and Portal Hypertension – The Undiscovered Country(J)Journal of Hepatology . 2014
  • 5Reiner Wiest,Melissa Lawson,Markus Geuking.Pathological bacterial translocation in liver cirrhosis[J]. Journal of Hepatology . 2014 (1)
  • 6Monika Ferlitsch,Thomas Reiberger,Matthias Hoke,Petra Salzl,Bernadette Schwengerer,Gregor Ulbrich,Berit Anna Payer,Michael Trauner,Markus Peck‐Radosavljevic,Arnulf Ferlitsch.??Von Willebrand factor as new noninvasive predictor of portal hypertension, decompensation and mortality in patients with liver cirrhosis(J)Hepatology . 2012 (4)
  • 7Pablo Bellot,Juan Carlos García‐Pagán,Rubén Francés,Juan G. Abraldes,Miguel Navasa,Miguel Pérez‐Mateo,José Such,Jaime Bosch.??Bacterial DNA translocation is associated with systemic circulatory abnormalities and intrahepatic endothelial dysfunction in patients with cirrhosis(J)Hepatology . 2010 (6)
  • 8Masahito Uemura,Yoshihiro Fujimura,Saiho Ko,Masanori Matsumoto,Yoshiyuki Nakajima,Hiroshi Fukui.??Pivotal role of ADAMTS13 function in liver diseases(J)International Journal of Hematology . 2010 (1)
  • 9X. W.ZHENG,D. Z.SHANG,X. L.ZHENG.??Inflammatory cytokines inhibit ADAMTS13 synthesis in hepatic stellate cells and endothelial cells(J)Journal of Thrombosis and Haemostasis . 2008 (7)
  • 10Yasuko Iwakiri,Roberto J. Groszmann.Vascular endothelial dysfunction in cirrhosis[J]. Journal of Hepatology . 2007 (5)

二级参考文献14

  • 1Meetings[J].World Journal of Gastroenterology,2010,16(4). 被引量：13
  • 2Salvador Augustin,Antonio González,Joan Genescà.Acute esophageal variceal bleeding:Current strategies and new perspectives[J].World Journal of Hepatology,2010,2(7):261-274. 被引量：44
  • 3Anca Trifan,Stefan Chiriac,Carol Stanciu.Update on adrenal insufficiency in patients with liver cirrhosis[J].World Journal of Gastroenterology,2013,19(4):445-456. 被引量：11
  • 4Martin Blachier,Henri Leleu,Markus Peck-Radosavljevic,Dominique-Charles Valla,Fran?oise Roudot-Thoraval.The burden of liver disease in Europe: A review of available epidemiological data[J].Journal of Hepatology.2013(3)
  • 5Javier Fernández,Thierry Gustot.Management of bacterial infections in cirrhosis[J].Journal of Hepatology.2012
  • 6Puneeta Tandon,Angela DeLisle,Jeffrey E. Topal,Guadalupe Garcia–Tsao.High Prevalence of Antibiotic-Resistant Bacterial Infections Among Patients With Cirrhosis at a US Liver Center[J].Clinical Gastroenterology and Hepatology.2012(11)
  • 7Juan Acevedo,Aníbal Silva,Verónica Prado,Javier Fernández.The new epidemiology of nosocomial bacterial infections in cirrhosis: therapeutical implications[J].Hepatology International.2013(1)
  • 8Pablo Bellot,Rubén Francés,Jose Such.Pathological bacterial translocation in cirrhosis: pathophysiology, diagnosis and clinical implications[J].Liver Int.2012(1)
  • 9Salvatore Piano,Antonietta Romano,Silvia Rosi,Angelo Gatta,Paolo Angeli.Spontaneous bacterial peritonitis due to carbapenemase-producing Klebsiella pneumoniae: the last therapeutic challenge[J].European Journal of Gastroenterology & Hepatology.2012(10)
  • 10Srdan Novovic,Synne Semb,Henrik Olsen,Claus Moser,Jenny Dahl Knudsen,Christian Homann.First-line treatment with cephalosporins in spontaneous bacterial peritonitis provides poor antibiotic coverage[J].Scandinavian Journal of Gastroenterology.2012(2)

共引文献43

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二级引证文献3

World Journal of Gastroenterology
2016年 第19期

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