摘要
目的:探讨泮托拉唑钠中的主要活性成份和作用强度,为左旋泮托拉唑钠的临床开发提供依据。方法:采用随机数字表法,将70只SD大鼠分为7组,各组均单次尾静脉注射相应药物溶液,模型组、正常组给予等容量生理盐水,束水应激造成大鼠应激性胃溃疡,通过检测溃疡指数、溃疡抑制率、胃液pH值、H^+-K^+-ATP酶活性,评价左旋泮托拉唑钠的抗溃疡效果,并与右旋泮托拉唑钠和泮托拉唑钠进行比较。结果:左旋泮托拉唑钠中、高剂量组可以显著抑制束水应激性胃溃疡大鼠溃疡指数,升高胃液pH值,降低H^+-K^+-ATP酶活性(P <0. 05,P <0. 01);右旋泮托拉唑钠影响不显著,泮托拉唑钠与中剂量左旋泮托拉唑钠作用相当。结论:左旋泮托拉唑钠为泮托拉唑钠的主要活性成分。
Objective: To determine effect of pantolazole sodium on irritable stomach ulcer in rats,and evaluate its main active component,providing an experimental basis for the clinical development. Methods: A total of 70 SD rats were randomly divided into 7 groups. The corresponding drug solution was injected into each group from the tail vein,the model group and the normal group were given the same amount of normal saline. Irritable gastric ulcer was induced by water immersing. The ulcer index,ulcer inhibition rate,gastric juice PH value,and H+-K+-ATPase activity were detected. The effects of S(-)-pantoprazole sodium were compared with that of pantoprazole. Results: S(-)-pantoprazole sodium at 1. 8 and 3. 6 mg·kg-1 significantly inhibited the ulcer index,increased the p H value in gastric juice,and decreased the activity of H+-K+-ATPase activity( P < 0. 05,< 0. 01). The effects of S(-)-pantoprazole sodium were similar to that of pantoprazole. Conclusion: The main active component of pazoprazole sodium may be S(-)-pantoprazole.
作者
张君利
郭其
矫喜梅
王浩
杨晓丽
吕剑涛
ZHANG Jun-li;GUO Qi;JIAO Xi-mei;WANG Hao;YANG Xiao-li;LVJian-tao(Department of Pharmacy,Yantai Affiliated Hospital of Binzhou Medical University,Yantai 264100,China;Binzhou Medical University,Yantai 264100,China)
出处
《中国新药杂志》
CAS
CSCD
北大核心
2019年第3期370-374,共5页
Chinese Journal of New Drugs
基金
山东省自然科学基金(ZR2013HQ043)
