摘要
目的:探究阿帕替尼所致不良反应(adverse drug reaction,ADR)的发生情况及临床特点,为临床合理用药提供参考。方法:介绍3例临床药师参与的典型不良反应病例,并以阿帕替尼(apatinib)为关键词,检索2015年至今的维普中文科技期刊数据库、万方数据库及PubMed收载的资料,进行统计分析。结果:共检索到18例次不良反应,阿帕替尼所致不良反应以50岁以上人群为主(13例,72. 1%),发生时间集中在10～20 d(7例,38. 89%)和≥30 d(8例,44. 44%),累及的系统主要有皮肤损害(8例,44. 44%)和心血管系统(5例,27. 78%),临床主要表现为手足综合征、皮疹、溃疡、高血压、房颤等。结论:在临床合理使用阿帕替尼的同时,临床医师和临床药师均应加强其用药的监测,以减少不良反应的发生。
Objective:To study the general situation and characteristics of the adverse drug reactions(ADRs)associated with apatinib,so as to provide reference for clinical rational drug use.Methods:Three cases of typical ADRs of apatinib were introduced and the ADRs of apatinib published in Chinese VIP journal database,Wanfang database and Pub Med database from 2015 to now were collected and analyzed statistically.Results:Totally 18 patients were retrieved who had ADRs induced by apatinib,among whom patients over 50 years-old showed a higher incidence(13 cases,72.1%).ADRs of apatinib usually occurred during 10~20 d(7 cases,38.89%)and≥30 d(8 cases,44.44%)after medication.The main systems involved were skin lesions(8 cases,44.44%)and cardiovascular system(5 cases,27.78%).The ADRs and clinical manifestations induced by aptinib mainly included hand foot syndrome,ash,ulcers,hypertension,atrial fibrillation and so on.Conclusion:Clinicians and clinical pharmacists should use apatinib rationaly and strenthen monitoring on the use of apatinib to reduce the incidences of ADRs.
作者
谢燕瑾
沈丽蓉
陈玲
陈青莲
XIE Yan-jin;SHEN Li-rong;CHEN Ling;CHEN Qing-lian(Department of Pharmacy,the Third Affiliated Hospital of Zhejiang Chinese Medicine University,Hangzhou 310005,China;Department of Pharmacy,Sir Run Run Shaw Hospital,Zhejiang University School of Medicine,Hangzhou 313000,China;Department of Pharmacy,Affiliated Hospital of Nantong University,Nantong 226001,China;Department of Pharmacy,Zhejiang Xiaoshan Hospital,Hangzhou 311200,China)
出处
《中国新药杂志》
CAS
CSCD
北大核心
2019年第8期1021-1024,共4页
Chinese Journal of New Drugs
关键词
阿帕替尼
不良反应
临床药师
apatinib
adverse drug reactions
clinical pharmacists
