摘要
目的基于中医传承辅助平台V2.5(TCMISS V2.5)研究川崎病中药处方的用药规律。方法通过中国知网、维普、万方数据库收集1990~2015年中药治疗川崎病的处方,采用关联规则apriori算法等无监督数据挖掘方法,分析处方中各种药物的使用频次、药物之间的关联规则。结果对筛选出的154个中药处方进行分析,确定处方中药物的使用频次、药物之间的关联规则。结论中药治疗川崎病常用的药物以清热药、活血化瘀药、补阴药等为主,治法主要是清热泻火、养阴生津、活血化瘀。生石膏、生地黄、赤芍、连翘、玄参、牡丹皮、知母、金银花、水牛角是临床治疗川崎病常用的核心药物。
Objective: To analyze the medication rule in herbal for Kawasaki Disease by using Chinese medicine inheritance support system v2.5(TCMISS v2.5). Methods: Literatures were collected related to Chinese formulas treating Kawasaki Disease from Chinese National Knowledge Infrastructure,VIP database,and Wanfang database from 1990 to 2015,and then the data were entered into TCMISS v2.5 and composition principles were analyzed with data mining methods,such as revised mutual information and unsupervised hierarchical cluster. Results:Based on the analysis of 154 herbal prescriptions,the frequency and compatibility of the nature and flavor and medicinal herb′s meridian tropism and combinations were found,and association rules among the herbs were computed. Conclusion: Heat-clearing drugs and drug for invigorating blood circulation and eliminating stasis and yin-reinforcing drugs are most commonly used. The method of treatment for Kawasaki Disease is clearing heat-fire and nourishing yin and generating body fluid and promoting blood circulation to remove blood stasis. Gypsum,Radix rehmanniae recen,Radix Paeoniae Rubra,Forsythia suspensa,Radix scrophulariae,Moutan bark,Rhizoma anemarrhenae,Lonicera japonica and Buffalo Horn are the core herbs used in the herbal for Kawasaki Disease.
出处
《中国中医急症》
2015年第10期1755-1757,共3页
Journal of Emergency in Traditional Chinese Medicine
基金
罗笑容名医工作室
广东省岭南儿科学术流派
广东省中医院中医药科学技术研究专项资助(No.YK2013B2N18)
关键词
川崎病
组方规律
关联规则
聚类
Kawasaki Disease
Herbal fumigation
Association rules
Clustering algorithm
