摘要
目的:探讨分析清肝泻火消瘿方对甲状腺功能亢进性心脏病患者甲状腺相关激素和B型脑钠肽水平的影响。方法:符合纳入标准的甲状腺功能亢进性心脏病患者86例,采用随机数表法将其分为两组。其中治疗组43例,服用甲硫咪唑联合清肝泻火消瘿方;对照组43例,仅服用甲硫咪唑。观察两组患者甲状腺相关激素和B型脑钠肽水平的变化情况。结果:两组患者治疗前TSH、FT3、FT4及BNP水平比较差异不显著,无统计学意义(P> 0. 05)。治疗3个月后,两组FT3、FT4及BNP水平与治疗前比较均明显降低,TSH水平较治疗前明显增高,其中治疗组FT3、FT4水平在治疗1月、2月后均低于对照组治疗1月、2月后水平,差异均具有统计学意义(P <0. 05)。两组患者在治疗期间3个月TSH水平恢复率无显著差异;治疗2个月和3个月后两组患者FT3和FT4水平恢复率比较差异不显著(P>0. 05)。而治疗1个月后,治疗组的FT3恢复率41. 86%和FT4恢复率44. 18%明显高于对照组FT3的27. 91%和FT4恢复率23. 26%,差异具有统计学意义(P <0. 05)。两组患者初始服用甲硫咪唑剂量比较无明显差异(P> 0. 05),而治疗1个月,2个月,3个月后治疗组甲硫咪唑口服剂量低于对照组;对照组不良反应发生率为11. 63%(5/43)明显高于治疗组的4. 65%(2/43),差异均具有统计学意义(P <0. 05)。结论:清肝泻火消瘿方联合甲硫咪唑可以快速降低患者体内甲状腺激素浓度,改善甲状腺功能亢进性心脏病患者心功能,并减少甲硫咪唑用量,从而降低不良反应发生率,值得在临床上推广。
Objective: To investigate the effects of Qinggan Xiehuo Xiaoying Formula on thyroid-related hormone and B-type natriuretic peptide in patients with hyperthyroid cardiopathy. Methods: 86 patients with hyperthyroid cardiopathy were randomly divided into the treatment group(n = 43) and the control group(n = 43). The control group was treated with Metformin;on which basis,the treatment group was also treated with Qinggan Xiehuo Xiaoying Formula. The levels of thyroid-related hormone and B-type natriuretic peptide were observed in the two groups. Results: There were no significant differences in the levels of TSH,FT3,FT4 and BNP between the two groups before the treatment(P > 0. 05). After 3 months of treatment,the levels of FT3,FT4 and BNP were significantly lower than those before the treatment in the two groups,and the level of TSH was significantly higher than that before the treatment;of which the levels of FT3 and FT4 were lower in the treatment group than those in the control group after one month and two months of treatment(P <0. 05). There was no significant difference in the recovery rate of TSH between the two groups during the three months of treatment(P > 0. 05);there were no significant differences in the recovery rates of FT3 and FT4 between the two groups after two months and three months of treatment(P > 0. 05). After one month of treatment,the FT3 recovery rate of the treatment group was 41. 86% and the recovery rate of FT4 was 44. 18%,which were significantly higher than 27. 91% and 23. 26% respectively in the control group(P < 0. 05).There was no significant difference in the initial doses of Methimazole between the two groups(P > 0. 05),but the oral dose of Methimazole in the treatment group was lower than that in the control group after one month,two months,and three months of treatment. The incidence rate of adverse reactions in the control group was11. 63%(5/43),which was significantly higher than 4. 65%(2/43) in the treatment group(P < 0. 05).Conclusion: Qinggan Xiehuo Xiaoying Formula combined with Methimazole can rapidly reduce the concentration of thyroid hormone,improve heart function,and reduce the dose intake of Methimazole,thereby reducing the incidence of adverse reactions when treating hyperthyroid cardiopathy. It is worthy of clinical promotion.
作者
何明清
石爱华
何建亚
HE Mingqing;SHI Aihua;HE Jianya(Zhoukou Hospital of TCM,Zhoukou 466000,China)
出处
《中医药信息》
2019年第2期69-73,共5页
Information on Traditional Chinese Medicine
