摘要
目的 :探讨肾移植患者术后不同合并用药对他克莫司(FK506)血药浓度的影响。方法 :回顾性收集我院2016年1-12月的126例肾移植患者的158例次血药浓度监测数据及患者一般生物学资料,按不同的合并用药分为四组,采用统计学SPSS 20.0软件和"M±QR"分析不同合并用药对血药浓度的影响。结果:四组患者一般生物学资料差异无统计学意义(P>0.05);患者中低于治疗窗范围的(<5 ng/m L)15例,占9.5%;在治疗窗范围的(5~15 ng/m L)142例,占89.9%;高于治疗窗范围的仅有1例,占0.6%。在相同日服药剂量情况下,血药浓度的差异无统计学意义(P>0.05);术后时间相同阶段的情况下,四组之间FK506的血药浓度差异无统计学意义(P>0.05)。结论 :合并使用地尔硫?和五脂胶囊等可提高FK506血药浓度,为患者节省费用,但在使用初期需密切监测其血药浓度。
Objective:To investigate the influence of different drug combination on concentration of tacrolimus(FK506) in blood of patients with renal transplant. Methods:The 158 test results of FK 506 concentration in blood of 126 patients with renal transplant in The Second Hospital of Shanxi Medical University from January to December 2016 as well as the general biological information of patients were collected retrospectively, divided into four groups according to the drug combinations, and analyzed for the influence on tacrolimus concentration in blood by using SPSS 20.0 software and median-interquartile range(M±QR). Results:The general biological information of patients in four groups showed no statistical difference(P>0.05). The tacrolimus concentration in blood of 15 patients(9.5%) were lower than the range of therapeutic window(<5 ng/m L), while those in 142 patients(89.9%) were in the range of therapeutic window(5~15 ng/m L), and that in only one patient(0.6%) was higher than the range of therapeutic window. The blood drug concentrations of patients treated with drugs at the same daily dosages showed no statistical difference(P>0.05). The tacrolimusin concentrations in blood of patients at the same postoperative stages showed no statistical significance(P>0.05). Conclusion:The combination of diltiazem with five fat capsules increased the FK506 concentration in blood, which decreased the cost. However, the FK506 concentration in blood should be monitored strictly, especially at the early stage of administration.
出处
《中国执业药师》
CAS
2017年第4期36-39,43,共5页
China Licensed Pharmacist
关键词
他克莫司
肾移植
合并用药
血药浓度
Tacrolimus
Kidney Transplant
Drug Combination
Blood Drug Concentration
