摘要
目的 :分析在无痛胃肠镜诊疗中不同比例丙泊酚/依托咪酯混合液的麻醉效果和安全性。方法 :选取我院2015年3月-2017年1月行无痛胃肠镜诊疗的120例患者,按随机数字表法分为对照组和观察1组、观察2组,各40例。对照组无痛胃肠镜检查前丙泊酚/依托咪酯混合液麻醉用量比为10 mg∶1 mg,观察1组无痛胃肠镜检查前丙泊酚/依托咪酯混合液麻醉用量比为10 mg∶2 mg,观察2组无痛胃肠镜检查前丙泊酚/依托咪酯混合液麻醉用量比为10 mg∶4 mg。观察三组的平均动脉压(MAP)、心率(HR)、检查时间、诱导时间、苏醒时间、离院时间和不良反应。结果 :三组在麻醉后2 min的MAP值均低于诱导前(P<0.05),三组间在诱导前、麻醉后2 min和检查时的HR和MAP值比较均无统计学差异(P>0.05);观察1组离院时间和诱导时间均显著低于对照组和观察2组(P<0.05);观察1组不良反应发生率明显低于对照组和观察2组(P<0.05)。结论 :10 mg∶2 mg的丙泊酚/依托咪酯混合液能够有效地缩短无痛胃肠镜检查患者的麻醉诱导时间和离院时间,维持患者心血管和呼吸的稳定,降低患者的不良反应率。
Objective:To analyze the anesthetic effect and safety of different proportions of propofol/etomidate mixture in the treatment of painless gastrointestinal endoscopy. Methods:120 cases of painless gastroenteroscopy in our hospital from March 2015 to January 2017 were selected and randomly divided into control group(40 cases), observation group 1(40 cases) and observation group 2(40 cases). The control group was narcotized with propofol/etomidate mixture(10 mg:1 mg) before painless gastrointestinal endoscopy. The observation group 1 were narcotized with propofol/etomidate mixture(10 mg:2 mg), and observation group 2 were narcotized with propofol/etomidate mixture(10 mg:4 mg). The average arterial pressure(MAP), heart rate(HR), examination time, induction time, recovery time, time of departure from the hospital and adverse reaction were observed in the three groups. Results:The MAP value of three groups after anesthesia was lower than that before induction(P<0.05). There was no significant difference in the values of HR and MAP of the three groups before induction, 2 min after anesthesia and at the time of examination(P>0.05). The time of hospital departure and induction time in the observation groups 1 were significantly lower than those in the control group and the observation group 2(P<0.05). The incidence of adverse reactions in the observation groups 1 was significantly lower than that in the control group and the observation group 2(P<0.05). Conclusion:The propofol/etomidate mixture with a ratio of 10 mg:2 mg can effectively shorten the anesthetic induction time and departure time of patients with painless gastrointestinal endoscope, maintain cardiovascular and respiratory stability, and reduce the adverse reaction rate of patients.
出处
《中国执业药师》
CAS
2018年第2期59-61,65,共4页
China Licensed Pharmacist
关键词
丙泊酚/依托咪酯混合液
比例
无痛胃肠镜
Propofol/Etomidate Mixed Liquid
Proportion
Painless Gastrointestinal Endoscopy
