摘要
目的 :探讨坦索罗辛缓释胶囊联合米氮平对慢性无菌性前列腺炎(CAP)伴抑郁患者负性情绪及生活质量的影响。方法 :选取2013年11月-2016年10月我院收治的96例CAP患者,根据治疗方案不同分为两组,各48例。对照组给予坦索罗辛缓释胶囊(0.2 mg,qn)治疗,观察组在此基础上联合米氮平(15~30 mg,qd)治疗。比较两组治疗前后负性情绪[汉密尔顿焦虑量表(HAMA)、汉密尔顿抑郁量表(HAMD)]评分及生活质量评分,并统计两组治疗期间不良反应发生率。结果 :治疗前,两组HAMA、HAMD评分及生活质量评分差异无统计学意义(P>0.05),经治疗,观察组HAMA、HAMD评分低于对照组,生活质量评分高于对照组,差异有统计学意义(P<0.05);观察组不良反应发生率为10.42%,与对照组的6.25%比较差异无统计学意义(P>0.05)。结论 :坦索罗辛缓释胶囊联合米氮平治疗CAP临床效果显著,可有效缓解患者负性情绪,改善生活质量,且定安全性高。
Objective:To explore the effect of tamsulosin sustained-release capsule combined with mirtazapine on negative emotion and quality of life in patients with chronic aseptic prostatitis(CAP) and depression. Methods:96 patients in our hospital from November 2013 to October 2016 were selected and divided into two groups: control group(n=48) and observation group(n=48) according to different treatment methods. The patients in the control group were treated with tamsulosin sustained-release capsule(0.2 mg, qn), and the patients in the observation group were further treated with mirtazapine(15~30 mg, qd). The scores of negative emotions [Hamilton Anxiety Scale(HAMA), Hamilton Depression Scale(HAMD)] and quality of life before and after treatment in the two groups were compared, and the incidence of adverse reactions during treatment in the two groups was statistically analyzed. Results:Before treatment, there was no significant difference in the scores of HAMA, HAMD and quality of life between the two groups(P>0.05). After treatment, the scores of HAMA and HAMD in the observation group were lower than those in the control group and the score of quality of life score was higher than that in the control group, and the difference was statistically significant(P<0.05). The incidence of adverse reactions was 10.42%(5/48) in the observation group and 6.25% in the control group(3/48), and the difference was not statistically significant(P>0.05). Conclusion:Tamsulosin sustained-release capsule combined with mirtazapine has significant clinical therapeutic effect on CAP, which can effectively alleviate negative emotions of patients and improve quality of life, and has high safety.
出处
《中国执业药师》
CAS
2018年第5期8-10,14,共4页
China Licensed Pharmacist
关键词
慢性无菌性前列腺炎
坦索罗辛缓释胶囊
米氮平
负性情绪
生活质量
Chronic Aseptic Prostatitis
Tamsulosin Sustained Release Capsule
Mirtazapine
Negative Emotion
Life Quality
