摘要
目的:探讨喜炎平联合丙种球蛋白治疗重症手足口病的疗效及对患儿降钙素原(PCT)、C反应蛋白(CRP)和心肌酶的影响。方法:选取2016年1—12月我院收治的78例重症手足口病患儿为研究对象,按随机数字表法分为对照组和观察组,各39例。两组入院后均行常规治疗,对照组采用喜炎平注射液[5 mg/(kg·d),qd]治疗,观察组在对照组基础上加用丙种球蛋白[1 g/(kg·d)]治疗,比较两组临床疗效、治疗前后PCT、CRP和心肌酶水平变化情况。结果:观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05);观察组PCT、CRP、肌酸肌酶同工酶(CK-MB)水平低于对照组,差异有统计学意义(P<0.05)。结论:喜炎平联合丙种球蛋白治疗小儿重症手足口病的效果显著,可有效降低PCT、CRP和CK-MB水平,值得临床推广应用。
Objective: To investigate the efficacy of xiyanping combined with gamma globulin in the treatment of severe hand-foot-and-mouth disease and effect on procalcitonin(PCT), C-reactive protein(CRP) and myocardial enzyme in children. Methods: 78 cases of children with severe hand-foot-and-mouth disease admitted to our hospital from January to December 2016 were selected as study subjects and randomly divided into control group and observation group, 39 cases in each group. The children in the two groups received conventional treatment after admission. The children in the control group were treated with xiyanping injection [5 mg/(kg·d), qd]. The children in the observation group were further treated with gamma globulin [1 g/(kg·d)]. The clinical efficacy and changes in the levels of PCT, CRP and myocardial enzyme before and after treatment were compared between the two groups. Results: The total effective rate in the observation group was significantly higher than that in the control group(P<0.05). The levels of PCT, CRP and creatine kinase isoenzyme MB(CK-MB) in the observation group were significantly lower than those in the control group(P<0.05). Conclusion: Xiyanping combined with gamma globulin has a significant effect in the treatment of severe hand-foot-and-mouth disease in children, which can effectively reduce the levels of PCT, CRP and CK-MB, and is worthy of clinical application.
出处
《中国执业药师》
CAS
2018年第9期32-34,共3页
China Licensed Pharmacist
关键词
重症手足口病
儿童
喜炎平
丙种球蛋白
Severe Hand-foot-mouth Disease
Child
Xiyanping
Gamma Globulin
