摘要
目的:观察不同剂量结合雌激素(CEE)联合地屈孕酮对围绝经期综合征(MPS)患者性激素的影响。方法:选择2017年1月—2017年12月我院收治的PMS患者114例,应用随机数字表法分为低剂量组、标准剂量组,各57例。低剂量组接受低剂量CEE(0.3 mg,qd)、地屈孕酮(10 mg,qd)治疗,标准剂量组接受标准剂量CEE(0.625 mg,qd)、地屈孕酮(10 mg,qd)治疗。观察两组临床疗效、治疗前后性激素指标[卵泡刺激素(FSH)、雌二醇(E2)]及不良反应。结果:两组总有效率、乳房胀痛生率比较,差异无统计学意义(P> 0.05);治疗后两组FSH水平均较治疗前低,差异有统计学意义(P <0.05),但两组间比较,差异无统计学意义(P> 0.05);治疗后标准剂量组E2水平较低剂量组高,差异有统计学意义(P <0.05);低剂量组阴道不规则流血发生率较标准剂量组低,差异有统计学意义(P <0.05)。结论:低剂量CEE、地屈孕酮联合治疗MPS即可达到改善临床症状、性激素水平的目的,且安全性更佳。
Objective:To observe the effect of different doses of conjugated estrogen(CEE)combined with dydrogesterone on sex hormones in patients with peri-menopausal syndromes(MPS).Methods:114 patients with PMS admitted to our hospital from January 2017 to December 2017 were selected and randomly divided into a lowdose group and a standard-dose group,57 cases each.The patients in the low-dose group were treated with low-dose CEE(0.3 mg,qd)and dydrogesterone(10 mg,qd),and the patients in the standard-dose group were treated with standard-dose CEE(0.625 mg,qd)and dydrogesterone(10 mg,qd).The clinical efficacy,sex hormone indexes[follicle stimulating hormone(FSH),estradiol(E2)]before and after treatment and adverse reactions in the two groups were observed.Results:There were no statistically signi?cant differences in the total effective rate and breast tenderness between the two groups(P>0.05).The FSH levels in the two groups after treatment were lower than those before treatment,and the difference was statistically signi?cant(P<0.05),but the difference between the two groups was not statistically signi?cant(P>0.05).After treatment,the E2 level in the standard-dose group was higher than that in the lower-dose group,and the difference was statistically signi?cant(P<0.05).The incidence of irregular vaginal bleeding in the low-dose group was lower than that in the standard-dose group,and the difference was statistically significant(P<0.05).Conclusion:Low-dose CEE combined with dydrogesterone can achieve the purpose of improving clinical symptoms and sex hormone levels in the treatment of MPS,and has better safety.
作者
姜平平
Jiang Ping-ping(Department of Gynecology and Obstetrics,Affiliated Hospital of Xinyang Vocational and Technical College,Xinyang Henan 464000,China)
出处
《中国合理用药探索》
CAS
2019年第5期140-142,共3页
Chinese Journal of Rational Drug Use
关键词
围绝经期综合征
结合雌激素
地屈孕酮
性激素
Peri-menopausal Syndrome
Conjugated Estrogen
Dydrogesterone
Sex Hormone
