期刊文献+

盐酸纳美芬对颅脑损伤患者术后脑血流动力学及认知功能的影响 被引量:4

Effect of Nalmefene Hydrochloride on Cerebral Hemodynamics and Cognitive Function in Patients with Craniocerebral Injury
下载PDF
导出
摘要 目的:分析盐酸纳美芬对颅脑损伤患者术后脑血流动力学及认知功能的影响。方法:选取2017年2月—2019年1月本院收治的颅脑损伤患者80例,以随机数字表法分为两组,各40例。两组在入组前均终止其他治疗,并均予以常规治疗,对照组予以亚低温治疗,观察组在对照组基础上予以盐酸纳美芬[0.7 mg/(kg·h),bid,]治疗。比较两组脑血流动力学指标、血清相关指标及认知功能。结果:观察组治疗后大脑双侧动脉收缩期峰值血流速度(Vs)、平均血流速度(Vm)、简易精神状态检查(MMSE)评分均高于对照组,搏动指数(PI)、S100-β、神经胶质纤维酸性蛋白(GFAP)水平低于对照组,差异有统计学意义(P <0.05)。结论:盐酸纳洛美用于治疗颅脑损伤可有效改善患者的脑血流动力学指标与认知功能,减轻脑神经损伤。 Objective:To analyze the effect of nalmefene hydrochloride on cerebral hemodynamics and cognitive function in the patients with craniocerebral injury.Methods:80 patients with craniocerebral injury admitted to our hospital from February 2017 to January 2019 were selected and randomly divided into two groups,40 cases each.The patients in the two groups terminated other treatments before admission,and were given conventional treatment.The patients in the control group were further treated with mild hypothermia,and the patients in the observation group were given nalmefene hydrochloride[0.7 mg/(kg.h),bid]on the basis of the control group.The cerebral hemodynamic indexes,serum correlative indexes and cognitive function were compared between the two groups.Results:The peak systolic blood?ow velocity(Vs),mean blood?ow velocity(Vm)and mini-mental state examination(MMSE)scores in bilateral cerebral arteries in the observation group were higher than those in the control group,while the levels of pulsatility index(PI),S100-β,glial?brillary acidic protein(GFAP)were lower than those in the control group,and the differences were statistically signi?cant(P<0.05).Conclusion:Nalmefene hydrochloride for the treatment of craniocerebral injury can effectively improve cerebral hemodynamic indexes and cognitive function of the patients and reduce cranial nerve injury.
作者 苗鹏飞 Miao Peng-fei(DepartmentⅡof Neurology,the First People’s Hospital of Shangqiu City,Shangqiu Henan 476100,China)
出处 《中国合理用药探索》 CAS 2019年第5期162-164,共3页 Chinese Journal of Rational Drug Use
关键词 颅脑损伤 盐酸纳美芬 脑血流动力学 认知功能 Craniocerebral Injury Nalmefene Hydrochloride Cerebral Hemodynamics Cognitive Function
  • 相关文献

参考文献8

二级参考文献87

  • 1陆兆丰,贾锋,邱永明,罗其中,江基尧.亚低温对创伤性脑损伤后线粒体α-酮戊二酸脱氢酶活性的影响[J].中华神经外科杂志,2006,22(11):659-662. 被引量:29
  • 2彭桂兰,王央丹.小儿脑损伤综合征并听力障碍不同干预阶段临床分析[J].中国儿童保健杂志,2007,15(5):536-537. 被引量:3
  • 3Vink R, Mclntosh TK, Rhomhanyi R, et al. Opiate antagonist nalmefene improves intracellular free Mg2+, bioenergetic state, and neurologic outcome following traumatic brain injury in rats[J]. J Neurosci, 1990, 10(11): 3524-3530.
  • 4Xu J, Ma W, Hu D. Meta-analysis of nalmefene on acute severe traumatic brain injury[J]. Basic Clin Pharmacol Toxicol, 2014, ll5(Suppl 1): 203.
  • 5陈继军,赵兵刚,李超,等.盐酸纳美芬治疗急性重型颅脑损伤的疗效观察[C].2011北京协和急诊医学国际高峰论坛,2011:291-292.
  • 6Hauser KF, Foldes JK, Turbek CS. Dynorphin A (1-13) neurotoxicity in vitro: opioid and non-opioid mechanisms in mouse spinal cord neurons[J]. Exp Neurol,2012, 160(2): 361-375.
  • 7Sherwood TW, Askwith CC. Dynorphin opioid peptides enhanceacid-sensing ion channel 1 a activity and acidosis- induced neuronal death[J]. Neurosci, 2013, 29(45): 14371-14380.
  • 8Vink R, Portoghese PS, Faden AI. Kappa-opioid antagonist improvescellular bioenergetics and recovery after traumatic brain injury[J]. Am J Physiol, 2012, 261(6 Pt 2): R1527-1532.
  • 9Faden AI. Role of thyrotropin-releasing hormone and opiate receptor antagonists in limiting central nervous system injury[J]. Adv Neurol, 2013, 47: 531-546.
  • 10Ammon-Treiber S, Stolze D, Schrder H, et al. Effects of opioid antagonists and morphine in a hippocampal hypoxia/ hypoglycemiamodel[J]. Neuropharmacology, 2012, 55(8): 1160- 1169.

共引文献91

同被引文献36

二级引证文献28

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部