肿瘤细胞死亡形式对巨噬细胞功能的影响及其机制
摘要
肿瘤的非手术治疗手段多以诱导肿瘤细胞死亡作为治疗终点。但越来越多的研究表明 ,肿瘤细胞不同的死亡形式对于免疫细胞 ,特别是巨噬细胞功能有着完全不同的影响 ,凋亡的肿瘤细胞抑制巨噬细胞的抗肿瘤作用 ,而坏死的肿瘤细胞则完全相反。现综述这一现象及其可能的机制。
出处
《国外医学(肿瘤学分册)》
2004年第2期90-92,共3页
Foreign Medical Sciences (Cancer Section)
参考文献20
-
1Savill J,Fadok V.Corpse clearance defines the meaning of cell death.Nature,2000,402(6805) :784-788.
-
2Barker RN,Erwig LP,Hill SK,et al.Antigen presentation by macrophages is enhanced by the uptake of necrotic,but not apoptotic,cells.Clin Exp Immunol,2002,127(2):220-225.
-
3Heriot AG,Marriott JB,Cookson S,et al.Reduction in cytokine production in colorectal cancer patients:association with stage and reversal by resection.Br J Cancer,2000,82(5):1009-1012.
-
4Reiter I,Krarnmer B,Schwamberger G.Cutting edge:differential effect of apoptotic versus necrotic tumor cells on macrophage antitumor activities.J Immunol,1999,163(4):1730- 1732.
-
5Ronchetti A,Rovere P,Iezzi G,et al.Immunogenicity of apoptotic cells on vivo:role of antigen load,antigen-presenting cells,and cytokines.J Immunol,1999,163(1):130-136.
-
6Gouhg MJ,Melcher AA,Ahmed A,et al.Macrophages orchestrate the immune response to tumor cell death.Cancer Res,2001,61(19):7240-7247.
-
7Bondanza A,Rovere P,Borri A,et al.Cytokine secretion associated with the clearance of apoptotic bodies in renal cell carcinoma patients.Int J Cancer,2001,91(5) :713-717.
-
8Fadok VA,Bratton DL,Rose DM,et al.A receptor for phosphatidylserine-specific clearance of apoptotic cells.Nature,2000,405(6782):85-90.
-
9Huynh ML,Fadok VA,Henson PM.Phosphatidylserine-dependent ingestion of apoptotic cells promotes TGF-beta1 secretion and the resolution of inflammation.J Clin Invest,2002,109(1):41-50.
-
10Matsuno R,Aramaki Y,Tsuchiya S.Involvement of TGF-β in inhibitory effects of negatively charged liposomes on nitric oxide production by macrophages stimulated with LPS.Biochem Biophys Res Commun,2001,281(3) :614-620.
-
1楼海亚,叶大风,陈怀增,吕卫国,傅云峰,谢幸.卵巢癌细胞死亡形式对巨噬细胞细胞毒作用的影响[J].中华妇产科杂志,2004,39(4):265-266.
-
2胡玉红,杨光,孙毅.自噬、自噬相关基因Beclinl与肿瘤关系的研究[J].医学信息(下旬刊),2009(4):198-199.
-
3陈敏,冯文莉,黄宗干.化疗药物诱导急性白血病细胞凋亡及机制[J].国外医学(输血及血液学分册),2001,24(5):406-408.
-
4巴桑卓玛.细胞凋亡与肿瘤[J].西藏科技,2004(12):47-50. 被引量:1
-
5马丽,陈旭.失巢凋亡与肿瘤关系的研究进展[J].山东医药,2012,52(12):98-100. 被引量:1
-
6张志才,邵增务,熊蠡茗,车彪,邓超,杨述华.顺铂诱导骨肉瘤细胞自噬及其与凋亡关系的体外研究[J].华中科技大学学报(医学版),2011,40(2):178-182. 被引量:12
-
7向前,王成业,许雪亮,刘双珍,徐和平.高三尖杉酯碱诱导视网膜母细胞瘤程序性死亡[J].中华眼底病杂志,1997,13(2):70-72.
-
8丁峰,付晓光.诱导胃癌细胞凋亡的研究进展[J].辽宁医学院学报,2007,28(1):53-55. 被引量:3
-
9刘树林,张周良,范清宇,张殿忠,郭爱林,龙华,杨彤涛,袁秀春.恶性骨肿瘤患者巨噬细胞功能、NK细胞活性和T细胞亚群的变化[J].细胞与分子免疫学杂志,2001,17(2):152-152. 被引量:1
-
10晏建军,沈锋,吴孟超.褪黑素对H22肝癌小鼠巨噬细胞功能的调节作用[J].第二军医大学学报,1996,17(6):558-560. 被引量:3