期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

人脑胶质瘤恶性进展相关基因表达谱中葡萄糖代谢相关基因的分析 被引量：2

Analysis of glucose metabolism-related genes in gene expression profiles associated with malignant progression of glioma
下载PDF
导出
摘要 目的　研究胶质瘤糖代谢增强时哪些基因从中发生显著变化。方法　根据已经建立的胶质瘤恶性进展相关基因表达谱 ,用生物信息学分析方法和 Gene Bank检索的资料分析其中葡萄糖代谢相关基因的变化。结果　在胶质瘤恶性进展中 ,与葡萄糖代谢相关的差异表达基因有 HK1、PFK、Py K、Tra、citratc synthase、isocitrate dehy-drogenase、L DH-A、L DH-B、Glut5、L-xylulose reductase共 10条。结论　上述的 10条基因涉及到多个代谢途径 ,可为进一步研究胶质瘤细胞葡萄糖代谢的分子机制提供线索 ,其中在磷酸戊糖途径中起关键作用的
作者 赵鹏 董军 黄强 王爱东 孙继勇 兰青
机构地区 苏州大学附属第二医院神经外科暨脑肿瘤研究室
出处 《实用肿瘤杂志》 CAS 北大核心 2004年第1期39-42,共4页 Journal of Practical Oncology
基金 国家自然科学基金(基金号:3 0 0 70 772 ) 江苏省高校自然科学基金项目(0 1KJB3 2 0 0 0 2 )资助
关键词 脑胶质瘤 葡萄糖代谢 基因表达 基因芯片
分类号 R739.4 [医药卫生—肿瘤]
  • 相关文献

参考文献4

二级参考文献15

  • 1Eisen M, Spellman PT, Brown PO, et al . Cluster analysis and display of genome-wide expression patterns. Proc Natl Acad Sci USA, 1998, 95:14863-14868.
  • 2David NL , Eric CH, J Gregory Caimcross. Glioma classification: a molecular reappraisal. Am Pathol, 2001,159:779-786.
  • 3Rickman DS, Bobek MP, Misek DE, et al. Distinctive molecular profiles of high-grade and low-grade gliomas based on oligonucleolide microarry analysis. Cancer Res. 2001.61: 6885-6891.
  • 4Reis RM, Konu-Lebleblicioglu D, Lopes JM, et al. Genetic profile of gliosarcomas. Am J Palhol. 2000.156:425-432.
  • 5Fuller GN, Hess KR, Rhee CH, et al. Molecular classification of human diffuse gliomas by multidimensional scaling analysis of gene expression profiles parallels morphology-based classification, correlates with survival, and reveals clinically-relevant novel glioma subsets. Brain Pathol ,2002,12:108-116.
  • 6Wolf HK, Muller MB, Spanle M, et al. Gangliogliorm: a detailed hispathological and immunohistochemical analysis of 61 cases. Acta neuropathol , 1994, 88: 166-173.
  • 7Mickle JP. Ganglioglioma in children: a review of 32 cases at the university of florida. Pediatr Neurosurg, 1992, 18: 310-314.
  • 8Hayashi Y, Iwato M, Hasegawa M, et al. Malignant trasformation of a gangliocytoma: ganglioglioma into a glioblastonta multiforme: a molecular genetic analysis. Neurosurg, 2001, 95: 138-142.
  • 9Aboody KS, Brown A, Rainov NG, et al. From the cover neural stem cells display extensive tropism for pathology in adult brain: evidence from intracranial glioma. Proc Nail Acad Sci USA, 2000, 97:12846-12851.
  • 10Li XN, Du ZW, Huang Q, et al. Growth in hibitory and differentiationinducing activity of dimethylformamide in cultured human malignant glioma cells. Neurosurgery, 1997,40:1250-1259.

共引文献26

同被引文献15

  • 1Quade R, Lobe LP. Prognositc efficacy of a histologic-cytochemical malignancy grading of squamous cell carcinoma in the head-neck region[ J]. Acta Histochen Suppl, 1984,30( 3 ) :81- 87.
  • 2Ikezaki K, Black KL, Conklin SG, et al. Histochemical evaluation of energy metabolism in rat glioma[ J]. Neurol Res, 1992, 14(4) :289-293.
  • 3Schaub J, Mauch K, Rreuss M. Metabolic flux analysis in Escherichia coli by integrating isotopic dynamic and isotopic stationary 13C labeling data[ J]. Biotechnol Bioeng, 2008,99 (5) :1170-1185.
  • 4Ross BD, Kingsley PB, Ben-Yoseph O. Measurement of penrose phosphate-pathway activity in a single incubation with [ 1, 6-13C 2,6,6-2H2 ] glucose [ J ]. Biochem J, 1994,302 ( Pt 1 ) :31-38.
  • 5Lee WN, Boros LG, Lira S, et al. Mass isotopomer study of the nonoxidative pathways of the pentose cycle with glucose [J]. Am J Physiol,1998,274(5 Pt 1) :E843-851.
  • 6Ramos KL, Colquhoun A. Protective role of glucose-6-phosphate dehydrogenase activity in the metabolic response of C6 rat glioma cells to polyunsaturated fatty acid exposure [ J]. Glia,2003,43 (2) :149-166.
  • 7Coleman MT, Alien N. Activities of enzymes of the hexose mouophosphate pathway in nervous system tumors induced by ethylnitrosourea[ J ]. Acta Neuropathol, 1978,41 ( 3 ) : 223- 227.
  • 8Quade R, lobe L P.Prognositc efficacy of a histologic-cytochemical malignancy grading of squamous cell carcinoma in the head - neck region[J].Acta Histochen Suppl, 1984,30 : 81 - 7.
  • 9Ikezaki K, Black K L, Conklin S G, et al . Histochemical evaluation of energy metabolism in rat glioma[J].Neurol Res, 1992, 14(4) :289- 93.
  • 10Kingsley Hickman P B, Ross B D, Krick T. Hexose mo - nophosphate shunt measurement in cultured cells with [ 1 - 13C] glucose: correction For endogenous carbon sources using [6-13C] glucose [J]. Anal Biochem, 1990,185 (2) : 235 - 237.

引证文献2

二级引证文献6

实用肿瘤杂志
2004年 第1期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部