摘要
目的 探讨丹酚酸 B(Sal B)对大鼠心肌缺血再灌注损伤 (MIRI)内皮素释放 (ET)及血栓素 /前列环素 (TXA2 / PGI2 )系统的影响。方法 大鼠心肌缺血 30 min后再灌注 1 2 0 min造成大鼠心肌缺血再灌注损伤模型 ,放免法测定给药前后血浆中 ET、TXB2 及 6- Keto- PGF1α的含量 ,观察 Sal B对 MIRI心肌的保护作用。结果 Sal B可以减少 ET及 TXB2 的释放 ,提高 PGI2 的含量。结论 Sal B可以减轻 MIRI,可能通过减少 ET的释放 ,改善 TXA2 / PGI2 系统的平衡状态 ,减轻心肌细胞的损伤。
Objective To investigate the effect of salvianolic acid B (Sal B) on the release of endothelin (ET) and TXA 2/PGI 2 system in myocardial ischemia reperfusion injury ( MIRI ) of rat.Methods MIRI model of rat was made by reperfusion injury about 120 minutes after myocardial ischemia about 30 minutes. The contents of ET, TXB 2 and 6-Keto-PGF 1α were detected by the method of radioimmunity.Results The Sal B could reduce the release of ET and TXB 2 and increase the content of PGI 2.Conclusions Sal B could relieve MIRI of rat probably by reducing ET of plasma, ameliorating the balance of TXA 2/PGI 2 system and protecting the injured myocardial cell.
出处
《中国老年学杂志》
CAS
CSCD
北大核心
2004年第2期127-128,共2页
Chinese Journal of Gerontology
基金
天津市卫生局资助课题 (课题编号 :970 2 2 )