摘要
目的:观察体外循环心内直视术时应用巴曲亭对凝血全酶时间 (ACT)、凝血酶原时间 (PT)、纤维蛋白原 (FIB)、部分凝血活酶时间 (APTT)、凝血酶时间 (TT)及血小板 (PL T)等凝血指标的影响。 方法 :择期体外循环心内直视术患者 5 2例 ,随机分为两组 :巴曲亭组 2 7例 ,对照组 2 5例。麻醉方法为全麻。巴曲亭组停体外循环后给巴曲亭 ,给药后 15 m in给予鱼精蛋白中和肝素 (1∶ 1) ,10 min后测 ACT;对照组停体外循环后即给予鱼精蛋白中和肝素 (1∶ 1) ,10 m in后测 ACT。于术前 1d、术后 1h检测 PT、FIB、PL T、APTT、TT等凝血指标 ,记录术后第 1天出血量。 结果:两组患者给予巴曲亭前后 PL T、PT、TT及 FIB差异均无统计学意义 ,术后 1h两组 TT差异有统计学意义 (P <0 .0 5 ) ,两组 APTT在术前和术后 1h差异均无统计学意义 ,但组内手术前后差异均有统计学意义 (P <0 .0 1)。肝素化前两组 ACT差异无统计学意义 (P >0 .0 5 ) ,但按相同的比例鱼精蛋白中和后两组的 ACT相比 ,巴曲亭组明显短于对照组 (P <0 .0 1)。术后第 1天巴曲亭组出血量与对照组相比差异有统计学意义 (0 .0 1<P <0 .0 5 ) 。巴曲亭组和对照组均未发现皮疹等过敏现象。结论:巴曲亭对 PL T、PT、FIB影响不大 ,但巴曲亭组 ACT、TT明显缩短 。
Objective: To investigate the influence of hemocoagulase for injection on activated clotting time (ACT),prothrombin time (PT),thrombin time (TT),activated partial thromboplastin time(APTT) and platelet(PLT) during open heart surgery with cardiopulmonary bypass(CPB). Methods: Fifty-two patients undergoing open heart surgery with CPB were randomly divided into two groups: hemocoagulase group (H,n=27) and control group (C,n=25). Patients in H group Hemocoagulase 1~2 U were injected when CPB were stopped. After 15 minutes,were injected protamine to neutralize heparin (1∶1),then monitored ACT after 10 minutes. In C group protamine were injected when CPB stopped,then monitored ACT after 10 minutes. In addition,all patients were respectively monitored PLT,FIB,PT,APTT,TT of preoperative and postoperative one hour and the volume of blood loss of the first postoperative day. Results: There was no significant difference in age,weight,sexu,operative times and CPB times between two groups;There was no significant difference in PLT,PT,and FIB between two groups. ACT and TT were significant shorter in H group than those in C group(P<0.05). The volume of blood loss of the first postoperative day in H group were significant lower than those in C group. Conclusion: Hemocoagulase for injection can shorten ACT and TT and it is a better haemostatic in open heart surgery with CPB.
出处
《新疆医科大学学报》
CAS
2004年第1期56-58,共3页
Journal of Xinjiang Medical University
关键词
巴曲亭
体外循环
心内直视术
凝血功能
hemocoagulase for injection
open heart surgery
CPB
blood coagulation function
