摘要
奥美拉唑20mg,qd,口服治疗活动性胃或十二指肠溃疡65例(Ome组:男59,女6;年龄41±13a)。雷尼替丁0.15g,bid,口服,治疗42例(Ran组:男39,女3;年龄42±11a)作比较。疗程4-6wk。服药后疼痛消除:Ome组90％在3d内,Ran组92％需7-8d。十二指肠溃疡愈合率:Ome组(43例)4wk达100％,Ran组(30例)70％(P<0.01),胃溃疡愈合率:Ome组(22例)6wk为95％,Ran组(12例)67％(P<0.01)
Sixty-five patients with active peptic ulcer (group Ome) were treated with omeprazole 20mg qd, po, while 42 patients with the same suffering (group Ran) were given ranitidine 0.15g bid po as control four to six wk as a course. Pain relieved within 3 d in 90% of the patients in group Ome and within 7-8 d in 92% of the patients in group Ran. The healing rate of duodenal ulcer (DU) at the end of wk 4 (4th wk) was 100% in the group Ome and 70% in the group Ran. The healing rate of gastric ulcer (GU) at wk 6 was 95% in the group Ome, and 67% in the group Ran. The differences between the healing rates of group Ome and group Ran in DU and GU were all statistical significant (P<0.01). The healing rate of duodenal ulcer was not affected by the size of the ulcer area. No adverse effects were found in this study.
出处
《新药与临床》
CSCD
北大核心
1992年第5期286-288,共3页
关键词
奥美拉唑
消化性溃疡
药物疗法
omeprazole/therapeutic use
ranitidine/therapeutic use
peptic ulcer/drug therapy
