摘要
目的 :探讨碱性成纤维细胞生长因子 (bFGF)和重组异种骨 (RBX)复合 (bFGF/RBX)后的临床应用。方法 :将bFGF/RBX用于脊柱后路融合 2例、股骨骨不连 2例、骨缺损修复 5例、成骨不全弯曲畸形截骨矫形 1例 ;于术前和术后 10d、 4、 8、 12周查静脉血Ca2 + 、p3 - 、AKP及摄片。结果 :(1)除 2例AKP值于术前、后变化显著外 ,其余 8例病例的AKP值及全部病例的Ca2 + 、p3 - 值均正常 ;(2 )X线平片显示 :骨痂生长丰富、愈合时间提前 ;(3 )无排异反应、感染 ,术后热均于术后 4～ 5d至正常。结论 :bFGF/RBX的成骨能力强 ,能缩短愈合时间 ,是组织相容性好、骨源丰富且安全的生物复合材料。
Objective: To explore the osteogenesis and osteoinductive capability of RBX with bFGF(bFGF/RBX)in clinical application.Methods:bFGF/RBX were used in curing 10 patients:2 cases were of bone grafting and arthrodesis of spine through posterior approach,2 cases were of femoral nonunion,5 cases were of bone defect,1 of osteotomy for deformity of osteopsathyrosis;Ca 2+ ,p 3- ,AKP of venous blood were measured before operation and 10 days,4weeks,12 weeks after implantation of bFGF/RBX respectively,bone radiographs were taken concomitantly.Results:All cases were followed up for 3～18 months postoperatively;(1)The blood level of Ca 2+ ,p 3- in all cases were in normal ranges,the level of AKP before and after bone transplantation did not changed significantly except in two cases;(2)Profuse callus?quicker remodeling and recovering were seen on radiograph;(3)Neither immune rejection nor infection were found in all cases,and their fever resolved 4～5 days postoperatively.Conclusion:bFGF/RBX is a safe combinating biomaterial with obvious capability of osteoinductive and osteogenesis,satisfactory histocompatibility and rich bone sources,it can shorten the period of bone healing obviously by clinical using for children cases.
出处
《中国矫形外科杂志》
CAS
CSCD
2004年第3期207-210,共4页
Orthopedic Journal of China
基金
江西省卫生厅资助项目 (NO .99- 4 2 )
