摘要
目的 探讨口腔颌面部肿瘤患者外周血T淋巴细胞核仁组成区嗜银蛋白 (Ag_NORs)的表达特点及其在口腔颌面部肿瘤诊断中的价值。方法 采用KL型肿瘤免疫图像分析系统及配套试剂 ,对 86例正常人、10 2例口腔颌面部良性肿瘤和 87例恶性肿瘤患者的外周血T淋巴细胞Ag_NORs进行检测 ,计算银染核仁面积与细胞核面积的比值 (I.S % ) ,然后进行综合分析。结果 口腔颌面部良性肿瘤组患者Ag_NORs表达与正常人组相比明显降低 ,良性肿瘤组平均I.S %值为 (5 72± 0 14 ) ,正常人组平均I.S%值为 (7 87± 0 12 ) ,两组间有显著性差异 (P <0 0 1) ;恶性肿瘤组患者Ag_NORs表达降低更为明显 ,平均I S%值为 (4 19± 0 13) ,与正常人组间有显著性差异 (P <0 0 1) ;良性肿瘤患者组与恶性肿瘤组之间平均I.S%值也有显著性差异 (P <0 0 1)。结论 外周血T淋巴细胞Ag_NORs表达与口腔颌面部肿瘤呈良好的相关性 ;
Objective To study the Ag-NORs expressive character of T lymphocyte in patients with oral and maxillofacial tumor and evaluate its diagnostic value for the patients. Methods Nucleolar organizer regions(NORs) of T lymphocyte from 86 normal adults, 102 patients with oral and maxillofacial benign tumors and 87 patients with oral and maxillofacial malignant tumors were analyzed through KL imaging system. Results There was significant difference among normal adults, benign and malignant patients (P<0 01). Their average I.S% values were 7 87±0 12, 5 72±0 14, 4 19±0 13, respectively. Conclusion The expression of Ag-NORs of T lymphocyte has definite relation with oral and maxillofacial tumors; detection of Ag-NORs might play valuable in diagnosis of oral and maxillofacial tumors.
出处
《华西口腔医学杂志》
CAS
CSCD
北大核心
2004年第1期38-39,42,共3页
West China Journal of Stomatology
