摘要
目的 证实腭裂修复术后硬腭裸露骨面是否是导致上颌骨继发畸形的主要原因 ,并对其机制进行探讨。方法 选用 3周龄雌性SD大鼠 4 8只 ,随机分成正常对照组和实验组 ,每组各 2 0只。正常对照组不作任何处理 ,实验组行左侧硬腭粘骨膜切除。其余 8只 3周龄雌性SD大鼠以同样方法行左侧硬腭粘骨膜切除 ,于术后 2、5、8、12d分别处死动物 2只 ,观察裸露骨的组织变化。结果 正常对照组右侧硬腭平均宽度与所有实验组右侧相比无差异 ;所有实验组左侧硬腭平均宽度明显小于右侧 ,裸露骨组织有慢性骨髓炎表现存在。结论 腭裂修复术后硬腭骨面裸露是导致上颌骨继发畸形的重要原因。其作用机制除了由于伤口收缩、瘢痕挛缩、局部血供减少及营养缺乏外 。
Objective To confirm if denuded bone on lateral aspects of the hard palate of surgical repairs of the cleft palate is the main reason of causing disturbance of facial growth and to investigate the mechanism.Methods 48 SD rats were employed in the study. Among them 40 animals were divided into normal control and experimental group randomly. Normal control was not operated. Hard palate mucoperiosteum on the left side in experimental group were excised. Left hard palate mucoperiosteum in another 8 female three-week-old SD rats were excised with same method and were sacrificed at 2nd, 5th, 8th, and 12th day, respectively. The 8 rats were used for histological research.Results The width of all left sides hard palates in experimental group was significantly narrower than right side, and demonstrated statistical difference. Chronic osteomyelitis on the denuded hard palate was observed.Conclusion The denuded bone wound might be a principal factor for the following maxillary growth deformity in cleft palate patients who received palatoplasty in childhood. The mechanism of causing the deformity might be wound and scar contraction, decreased blood flow and nutrition plus chronic osteomyelitis.
出处
《华西口腔医学杂志》
CAS
CSCD
北大核心
2004年第1期13-15,共3页
West China Journal of Stomatology
基金
高等学校优秀青年教师教学和科研奖励基金资助 (1 999年 )
