摘要
目的 :探讨药物注射硬化疗法的机理 ,比较四种硬化剂的硬化效果。 方法 :选择山羊为实验动物 ,将 10只山羊随机分成对照组 (2只 )和治疗组 (共 8只 ,每组 2只 )。对照组药物为生理盐水 ;治疗组药物分别为曲直灵、消痔灵、5%鱼肝油酸钠、磷霉素钠溶液。对山羊肢体静脉按照临床操作规范 ,分别注射上述药物 ,在给药后 3d、1周、2周、4周四个不同时间段解剖分离出所给药血管段 ,观察其组织病理形态学及超微结构的变化。 结果:四种硬化剂中 ,消痔灵、磷霉素钠对静脉血管的硬化效果好 ,且磷霉素钠主要由胶原纤维增生导致管壁增厚、管腔闭塞完全 ,副作用小 ,并发症少。 结论
ObjectiveTo compare the sclerotic effect of four sc lersantsMethodsGoats were used as experimental animals,10 goats were divided into control group and treating groups at random:in control group 0.9% sodium chloride was used and in treating groups Quzhiling(QZL)(曲直灵 ),Xiaozh iling(XZL)()消痔灵),5% Sodium morrhuate,and fosfomycin sodium were used respecti vely.The four sclerosants were injected respectively into the veins of each grou p accor ding to the criteria of clinic.The gosts'extremities were dissected for histopat hological examination 3 days-4 weeks after injection.Results Among the four groups,XZL group and fosfomycin sodium group had good effect in s clerosis.As for fosfomycin sodium group,the vascular wall became thicker and the lumen got obstructed through collagen fiber proliferation with less side effect s or complications.ConclusionInjection sclerotherapy shows good effect in the treatment of varicose vein of lower extremities experimental ly.
出处
《中国中西医结合外科杂志》
CAS
2004年第1期5-7,共3页
Chinese Journal of Surgery of Integrated Traditional and Western Medicine
基金
河南省科技攻关项目(001170626)
