摘要
目的 观察左旋卡尼汀治疗冠心病心力衰竭的长期临床疗效。 方法 选择冠心病并慢性心力衰竭患者 6 2例 ,随机分为两组 ,对照组 30例予洋地黄、利尿剂、血管扩张剂、ACEI或 β受体阻滞剂等常规药物 ;卡尼汀组 32例 ,在常规治疗的基础上加用国产卡尼汀 3g d治疗 1年。 结果 卡尼汀组心功能改善的临床显效率(75 % )和总有效率 (87 5 % )均较对照组 (5 3%和 6 0 % )显著提高 (P <0 0 5 ) ,总胆固醇、甘油三酯分别降低 18%和15 % ,高密度脂蛋白升高 14 % (P <0 0 1) ,E A、射血分数、左室短轴缩短率分别增加 2 1%、14 %、11% ,左室内径减小 10 % (P <0 0 5 ) ,且无不良反应。 结论 卡尼汀辅助治疗冠心病并慢性心力衰竭有较好疗效。
Objective To observe the cardiac functional effect of L carnitine(L CN) on the congestive heart failure(CHF) of patients with coronary heart disease Methods 62 cases of chronic CHF randomly received routine treatment(digitalis,diuretics,vasodilator,ACEI or β blocker) or on the basis of routine therapy or with the addition of L CN(3 0g /d,12 month) Results The total effective rate of L CN group and control group were 87 5% and 60%(P<0 05),respectively The serum total cholesterol and triglyceride decreased by 18%?15%,respectively HDL Cholesterol levels increased by 14%(P<0 01),E/A?Left ventricular ejecting fraction(LVEF),fractional shortening(FS) increased by 21%,14%,11%,respectively,Left ventricular diameter decreased by 10%(P<0 05) No adverse effects of the drug was observed Conclusion Routine therapy with the addilion of L CN might be a effective treatment for the cases of coronary heart disease combined with CHF
出处
《实用心脑肺血管病杂志》
2004年第1期1-3,共3页
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
