摘要
目的 测定急性一氧化碳中毒患者脑脊液 (CSF)S - 10 0 β蛋白变化 ,探讨其临床意义。 方法 采用酶联免疫吸附试验双抗体夹心法检测 35例急性一氧化碳中毒患者及 2 0例无神经系统疾病而需外科手术的腰麻患者CSFS - 10 0 β蛋白含量。结果 对照组与病例组患者CSF中S - 10 0 β蛋白含量分别为 (0 0 3± 0 0 1) μg/L ,(0 6± 0 36 ) μg/L (P <0 0 1) ;病例组CSF中S - 10 0 β蛋白含量与哥拉斯格昏迷评分呈相关性 ,相关系数 r为 - 0 975 (P <0 0 1) ;迟发性脑病发生组与未发生组CSF中S - 10 0 β蛋白含量分别为 (0 9± 0 18) μg/L ,(0 33± 0 16 ) μg/L (P <0 0 1)。 结论 检测急性一氧化碳中毒患者CSF中S -10 0 β蛋白含量的变化 ,有助于评估急性期脑组织受损的严重程度及预测迟发性脑病的发生。
Objective To explore the clinical value of S-100β in the cerebrospinal fluid (CSF) in the patients with acute carbon monoxide poisoning.Methods The levels of S-100β were measured by ELISA in samples of CSF collected from 35 patients with acute carbon monoxide poisoning and from 20 lumbar anesthesia patients without central nervous system diseases.Results The S-100β levels of CSF in the patients with acute carbon monoxide poisoning and in control group were(0.6±0.36) μg/L and (0.03±0.01) μg/L,respectively ( P <0.01).The S-100β levels of CSF in the patients with acute carbon monoxide poisoning related well to the Glasgow Coma Scale scores.The concentrations of S-100β in the patients with delayed encephalopathy and those without delayed encephalopathy were (0.9±0.18) μg/L and (0.33±0.16) μg/L,respectively ( P <0.01).Conclusion The concentrations of S-100β in CSF of the patients with carbon monoxide poisoning contribute not only to assess the severe degree in the acute stage,but also to predict the possibility of delayed encephalopathy.
出处
《中国急救医学》
CAS
CSCD
北大核心
2004年第3期189-190,共2页
Chinese Journal of Critical Care Medicine
关键词
脑脊液
一氧化碳中毒
脑病
S-100Β蛋白
Cerebrospinal fluid
Carbon monoxide poisoning
Encephalopathy
S-100β protein
