摘要
以聚乙二醇6000(简称PEG 6000)为载体制成吲哚美辛滴丸。测得滴丸的溶解度比原药吲哚美辛增大一倍多,剂量减半时,滴丸对大鼠胃的刺激性显著降低,且仍有抑制基础胃酸分泌的作用。
Indomethacin (IDM)-PEG 6000 pilules were prepared using PEG6000as the carrier. The solubility of IDM in IDM-PEG 6000 pilules was about twiceas much as pure IDM. When the effective dose of IDM -PEG 6000 was only half that ofIDM tablet, the irritation of IDM-PEG 6000 pilule on rat stomach was reducedsignificantly but it still manifested the action of inhibiting the secretion of basal gastricacid
出处
《药学学报》
CAS
CSCD
北大核心
1992年第3期227-230,共4页
Acta Pharmaceutica Sinica
关键词
吲哚美辛
滴丸
Indomethacin
PEG 6000
Pilule
