摘要
报道13个6,7-亚甲二氧基-1(2H,4H)-吖啶酮衍生物的合成。初步药理实验表明:合成的化合物均有不同程度的镇痛作用,其中化合物Ⅱe的镇痛效力最强。
Thirteen derivatives of 6, 7-methylenedioxy-1 (2H, 4H)-acridonewere prepared. The structures of all the compounds synthesized were characterized byelemental analysis, IR and ~1HNMR spectra. Compounds Ⅱa, Ⅱb, Ⅱd, Ⅱe, Ⅱf increased significantly the pain threshold using thehot- plate method.
出处
《药学学报》
CAS
CSCD
北大核心
1992年第4期256-260,共5页
Acta Pharmaceutica Sinica
关键词
止痛
吖啶酮
合成
1(2H, 4H)--acridone
Analgesic action
