摘要
从菊科值物黄花蒿(Artemisia annua L.)中分离得到的青蒿B(arteannuin B)是一个有α-次甲基五元环倍半萜内酯化合物。文献报道一些α-次甲基环内酯萜类化合物具有抗肿瘤活性,如模地胆宁(molephantinin)。
Arteannuin B (I) was converted to hydroxy lactones (Ⅶ, Ⅷ) by amixture of formic acid and sulfuric acid. Compound Ⅵ and Compound Ⅶ both showedactivity against leukemia P 388 cell in vitro. The rate of growth inhibition were 97.5%and 11.8% for(Ⅵ)and 80% and 52.6% for(Ⅶ)at the concentration of 10 and 1μg/mlrespectively. It seems that the antileukemia activity of 6- membered lactone is higher thanthat of 5- membered and the methylene group is necessary for the antileukemia activity.
出处
《药学学报》
CAS
CSCD
北大核心
1992年第4期317-320,共4页
Acta Pharmaceutica Sinica
关键词
黄芪蒿
青蒿B
抗肿瘤作用
α--methylene sesquiterpene lactone
Antileukemia activity
Arteannuin B
