摘要
以四氧嘧啶诱导糖尿病小鼠为实验模型 ,研究了不同分子链段的魔芋葡甘露聚糖KGM Ⅰ ,KGM Ⅱ ,KGM Ⅲ和魔芋精粉的降血糖效果。结果显示 ,当灌胃剂量为 1 5 g/kg时 ,小鼠血糖下降率分别为 5 5 37% ,80 6 0 % ,33 4 4 %和 4 0 9% ,以KGM Ⅱ的降糖效果最好。研究还显示KGM Ⅰ、KGM Ⅱ和魔芋精粉均可增强正常小鼠腹腔巨噬细胞的吞噬功能和由DNFB所致的迟发性变态反应 ,且KGM Ⅱ的效果显著强于KGM Ⅰ和魔芋精粉。
The antidiabetic effect of konjac glucomannan with different molecular chains on experimental diabetes mice was studied.The result showed that KGM-Ⅰ,KGM-Ⅱ,KGM-Ⅲ and konjac flour can lower blood sugar of alloxan-induced hyperglycemic mice.When the dose was 1.5 g/kg,the decrease rates of blood sugar was 55.37%,80.60%,33.44% and 40.9%, respectively.It also showed that KGM-Ⅱ (Po,0.2 g/kg.d×7d) can significantly intensify DTH induced by DNFB and improve phagocytosing function of peritoneal macrophage (PM Φ) separetely.
出处
《中药材》
CAS
CSCD
北大核心
2004年第2期110-113,共4页
Journal of Chinese Medicinal Materials
