摘要
目的 比较丙泊酚-麻黄碱混合液诱导和单独应用丙泊酚诱导在静脉注射罗库溴铵后对插管条件的影响。方法 采用双盲、前瞻、对照法将100例成年患者随机分成两组,A组给予丙泊酚2.5mg/kg和麻黄碱15mg/kg,B组静脉注射丙泊酚2.5mg/kg(两组均在30s内注完),两组均静脉注射罗库溴铵0.6mg/kg(5s注完),1min后进行气管插管,观察下颌松弛、声带位置及膈肌的反应以评价插管条件。结果 气管插管均成功,采用丙泊酚-麻黄碱诱导组插管条件评为“优秀”级(84％)明显高于单独采用丙泊酚组(32％)(P<0.05),虽然下颌松弛作用相似,但是丙泊酚-麻黄碱组在声带位置及对插管反应方面明显优于另一组,并且本组平均动脉压维持在诱导前水平。结论 丙泊酚-麻黄碱诱导较单独应用丙泊酚在给予罗库溴铵后能产生更好的插管条件。
Objective To compare intubating conditions after induction with a propofol-ephedrine combination or propofol alone, following administration of rocuronium. Methods A double blind, prospective,controlled trial was conducted. One hundred adult patients were randomly assigned to receive either propofol 2.5mg/kg and ephedrine 15mg/kg in combination or propofol 2.5mg/kg give over 30s, followed by rocuronium 0.6mg/kg given over 5s.Tracheal intubation was performed 1 min later Jaw relaxation,vocal cord position and diaphragmatic response were used to assess intubation conditions. Results Tracheal intubation was successful in all patients.There was a significantly higher proportion of intubating conditions graded as 'excellent' in the propofol-ephedrine group(84%) than in the propofol group (32%) (P<0.05).Vocal cord position and response to intubation were significantly better in the propofol-ephedrine group.Mean arterial pressure was maintained at pre-induction levels in the propofol-ephedrine group.Conclusion Induction with propofol and ephedrine in combination could provide significandy better intubating conditions than propofol alone,when followed by rocuronium.
出处
《实用医药杂志》
2004年第2期111-112,114,共3页
Practical Journal of Medicine & Pharmacy
关键词
丙泊酚
麻黄碱
罗库溴铵
插管条件
比较
Propofol Ephedrine Rocuronium Intubating conditions Comparison
