摘要
目的 探讨脂蛋白脂酶 (LPL)基因Ser4 4 7Ter变异与我国脑卒中发病危险的关系。方法 对 119例脑卒中患者及 77例非心脑血管病患者采用聚合酶链反应 限制片段长度多态性 ,观察LPL基因Ser4 4 7Ter变异在脑卒中患者中的分布 ,判断发病危险性。结果 脑梗死组CG型频率显著低于对照组 ;脑出血组CG型频率与对照组比较无差异 ;CG型携带者发生脑梗死的危险显著低于CC型。结论 LPL基因Ser4 4 7Ter变异与脑梗死发生有关 ,与脑出血无关 ,LPLSer4 4
Objective To investigate the correlation of strokes to the lipoprotein lipase(LPL)Ser447Ter variation in Changsha Hans.Methods This was a case control study, which enrolled 160 cases of strokes and 117 controls without strokes.Polymerase chain reaction restricted fragments length polymorphism was used to determine LPL genotype.Results Ischemic stroke patients showed significantly less frequency of CG genotype than controls.There was no statistical difference between hemorrhagic stroke and controls in the frequency of CG carrier.In logistic regression analysis,the risk of cerebral infarction in CG carriers was obviously lower than that in CC carriers(OR=0.428,P<0.05).Conclusion CG genotype is significantly associated with ischemic stroke, but not with hemorrhagic stroke.It may be a novel genetic marker for low risk of atherothrombotic cerebral infarction.
出处
《中华老年心脑血管病杂志》
CAS
2004年第1期28-31,共4页
Chinese Journal of Geriatric Heart,Brain and Vessel Diseases
关键词
脑血管意外
基因型
多态性
限制性片段长度
DNA突变分析
cerebrovascular accident
genotype
polymorphism,restriction fragment length
DNA mutational analysis
