摘要
真核生物中 ,染色质的基本单位是核小体。核小体由H2 A ,H2 B ,H3 ,H4构成的核心组蛋白八聚体及缠绕于其上的DNA构成。最近的研究结果表明 ,核心组蛋白的乙酰化 去乙酰化过程是调控基因活性的一个关键步骤[1] 。而含有组蛋白去乙酰化酶活性的分子有两类 :一类是与酵母RPD3同源的分子 ,另一类是与RPD3不同源的分子。它们各有其不同的来源 ,存在于各自的复合物中 ,催化不完全相同的组蛋白或其他蛋白质去乙酰化 ;这些去乙酰化酶与基因转录的调控存在着密切的关系 ,主要是介导基因转录的抑制。
In encaryote, nucleosome is the basic unit of chromosome, and it is composed of central histone octamer, which is made up of H 2A, H 2B, H 3, H 4 and DNA that bind it. Materials show that the central histone could affect transcription both in vivo and in vitro. The recent research shows that the process of acetylation and disacetylation is the key of regulating genes' activity. While there are two kinds of molecules that contain the disacetylase's activity: one is the homology with yeast RPD3, another one is not. They have the different sources, exist in the respective composite and catalyze different histone or the protein disacetylation. These all have close relationship with gene transcription regulation; especially it's inhibitory action. ;
出处
《中国生物工程杂志》
CAS
CSCD
2004年第2期19-21,共3页
China Biotechnology
