摘要
探讨帕米膦酸二钠(博宁)联合化疗对恶性肿瘤骨转移的临床疗效。方法:60例恶性肿瘤骨转移患者随机分为两组,每组30例,治疗组接受博宁联合化疗;对照组单用化疗,两组化疗方案相同。结果:治疗组疼痛总缓解率为83.3%,对照组为56.7%;骨病灶控制总有效率治疗组为53.3%,对照组为20.0%,治疗组疗效优于对照组(P<0.05),两组均无明显的不良反应。结论:帕米膦酸二钠联合化疗是目前治疗晚期恶性肿瘤骨转移的优选方案。
Objective:To evaluate therapeutic effect of pamidronate combined with chemotherapy in patients with cancer and bone metastases.Methods:60patients with cancer and bone metastases were divided randomly into two groups,30patients receive pamidronate combined with chemotherapy,30patients only receive chemotherapy.Chemotherapeutic program of two groups were same.Results:Response rate of bone pain relief was83.3%in pamidronate com-bined with chemotherapy group and56.7%in chemotherapy alone group.Response rate of bone metastases was53.3%in pamidronate combined with chemotherapy group and20.0%in chemotherapy alone group.The therapeutic effect of pamidronate combined with chemotherapy group is better than that of chemotherapy alone group(P<0.05).No serious side effect were found in both group.Conclusion:Pamidronate combined with chemotherapy is the best way to treat the patients with cancer and bone metastases at present.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2003年第8期572-575,共4页
Chinese Journal of Clinical Oncology
关键词
帕米膦酸二钠
化疗
肿瘤转移
Pamidronate Chemotherapy Neoplasm metastasis
