摘要
在相转移催化条件下,使α-D-乙酰基化溴代的葡萄糖、半乳糖、葡萄糖醛酸甲醋1a,1b,1C分别与2,6-二甲基-3,5-二氯-4-吡啶酚(俗称氯吡醇,氯羟吡啶)作用。
Three acetyl glycosides: 1-O-(2', 6'-dimethyl-3', 5'-dichloro-4'-pyridyl)-2,3,4,6-tetra-O-acetyl-β-D-glucopyranoside(2a), 1-O-(2',6'-dimethyl-3', 5'-dichloro-4'-pyridyl)-2,3,4,6-tetra-O-acetyl-β-D-galactopyranoside (2b) and methyl 1-O-(2',6'-dimethyl-3', 5'-dichloro-4'-pyridyl)-2,3, 4-tri-O-acetyl-β-D-glucopyranuronate(2c) were synthesized from2, 6-dimethyl-3, 5-dichloro-4-pyridinol and relevant glycosyl bromide in the presence ofphase transfer catalyst. The glycosides were treated with ammonia in methanol to obtain thecorresponding 1-O-(2', 6'-dimethyl-3', 5'-dichloro-4'-pyridyl)-β-D-glucopyranoside (3a), 1-O-(2', 6'-dimethyl-3', 5'-dichloro-4'-pyridyl)-β-D-galactopyranoside (3b) and 1-O-(2', 6'-dimethyl-3', 5'-dichloro-4'-pyridyl)-β-D-glucopyranuronamide (3c) respectively. 2c wastreated with sodium methoxide in methanol to obtain methyl 1-O-(2', 6'-dimethyl-3', 5'-di-chloro-4'-pyridyl)-β-D-glucopyranuronate (3d).
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
1992年第3期269-272,共4页
Chinese Journal of Organic Chemistry
基金
山东省自然科学基金
关键词
糖苷
氯吡醇
糖苷化
抗球虫
glycoside
clopidol
glycosidation
anti-eimeria
