摘要
目的 研究不同碘摄入量地区亚临床甲状腺功能减退症 (甲减 )的流行病学特点和影响转归的因素。方法 选择盘山、彰武和黄骅 3个农村社区 (分别为低碘、适碘和高碘地区 ) ,在入户调查的基础上行采样调查。测定血清TSH、甲状腺过氧化物酶抗体 (TPOAb)、甲状腺球蛋白抗体 (TGAb)、尿碘浓度及进行甲状腺B超检查 ,TSH异常者测定FT3 、FT4,筛选出 118例亚临床甲减患者。盘山和彰武社区于 2年后、黄骅社区于 1年后进行随访 ,再次进行以上检查。结果 盘山、彰武和黄骅社区亚临床甲减的患病率分别为 0 .73 %、2 .90 %和 5 .96%。亚临床甲减的病因 3 3 .1%是自身免疫性甲状腺疾病。在随访到的 93例亚临床甲减患者中有 4例女性进展为临床甲减。结论 随着碘摄入量的增加亚临床甲减的患病率增加 ,但无明显性别差异。随访研究证实女性、甲状腺自身抗体阳性是亚临床甲减患者进展至临床甲减的危险因素 ,碘摄入量与亚临床甲减的转归无关。
Objective To investigate epidemiological characteristics of subclinical hypothyroidism and factors influencing its outcome in the areas with different iodine intakes. Methods A cross-sectional epidemiological study in 3 rural communities of Panshan (iodine-deficient), Zhangwu (covered by iodinated salt from 1996) and Huanghua (iodine-excessive) was performed. Physical examination was performed in 3761 subjects and sera were sampled. The measurements included TSH, thyroid peroxidase antibody (TPOAb) and thyroglobulin antibody (TGAb) in the sera. Serum FT 3 and FT 4 were determined in the subjects with abnormal TSH. Urinary iodine concentration and thyroid B ultrasound were also examined. Ninety three patients with subclinical hypothyroidism accepted follow-up 1 year (Huanghua) or 2 years later (Panshan and Zhangwu) and above indexes were reexamined. Results TheprevalencesofsubclinicalhypothyroidisminPanshan, Zhangwu and Huanghua areas were 0.73%, 2.90% and 5.96% respectively, and 33.1% patients were with autoimmune thyroid disease. Of the 93 patients, 4womendevelopedclinicalhypothyroidism1-2 years later. Conclusion Higher prevalence of subclinical hypothyroidism is found in the area with higher iodine supply. Female and positive thyroid autoantibodies are the risk factors for the evolution of subclinical hypothyroidism into clinical hypothyroidism in this study. However, iodine intake is not related to the outcome of subclinical hypothyroidisms.
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
2003年第2期86-88,共3页
Chinese Journal of Endocrinology and Metabolism
基金
国家自然科学基金资助项目 (39970 350 )
美国中华医学基金会资助项目 (98 688ⅡTD)
