摘要
目的 探讨慢性心力衰竭 (CHF)患者血清瘦素水平改变及其与胰岛素抵抗、胰岛素水平之间的关系。方法 观察 4 0例CHF患者 (男性 )及 2 0例正常对照组 (男性 )血清瘦素水平变化 ,分析血清瘦素与胰岛素抵 [(以胰岛素敏感指数 (IAI)表示 ]、胰岛素水平之间的关系。结果 CHF组血清瘦素水平较正常对照组明显升高 [(6 .1±2 .1) μg/Lvs(3.8± 1.1) μg/L ,P <0 .0 1]。与对照组相比 ,CHF组胰岛素浓度升高 [(18± 3)mU/Lvs(10± 2 )mU/L ,P =0 .0 2 ],具有更高的IAI(4 .4± 0 .6vs3.8± 0 .7,P <0 .0 1)。血清瘦素与胰岛素水平及胰岛素抵抗程度 (IAI)显著正相关 (r =0 .80 3,0 .716 ,P <0 .0 1)。结论 CHF患者血清瘦素水平较正常对照组升高。CHF患者存在高胰岛素血症和胰岛素抵抗。血清瘦素与血胰岛素浓度和IAI呈正相关 ,提示胰岛素
Objective To explore the changes of serum leptin level in patients with chronic heart failure (CHF) and the relationship between leptin and insulin resistance and hyperinsulinemia. Methods Leptin levels were studied in 40 male patients with CHF and 20 male normal controls. The relationships between serum leptin level and insulin resistance and insulin concertration were also analyzed. Results Compared with the control group, CHF group had significant increased serum leptin level [( 6.1± 2.1)μg/L vs( 3.8± 1.1)μg/L, P< 0.01], higher fasting insulin levels[(18±3) mU/L vs (10±2) mU/L, P= 0.02] and higher degree of insulin resistance (indicated by IAI, 4.4± 0.6 vs 3.8± 0.7, P< 0.01). Serum leptin level correlated with fasting insulin and (IAI) (r= 0.803, 0.716, P< 0.01, respectively). Conclusion Serum leptin levels increase in patients with CHF. There are positive relationships between serum leptin and insulin concentration and insulin resistance, indicating a possible role of insulin-leptin axis in the increased energy expenditure observed in patients with CHF.
出处
《临床荟萃》
CAS
北大核心
2004年第5期241-243,共3页
Clinical Focus
