摘要
目的 探讨早期有效控制年龄依赖性癫性脑病 (ADEE)的理想药物。方法 选择ADEE患儿 48例 ,其中 2 1例初治单用托吡脂治疗 (初治组 ) ;传统一线抗癫药 (AEDs)治疗效果不佳 2 7例添加托吡脂治疗。结果 托吡脂早期单药治疗完全控制发作 11例 ,添加治疗 4例 ,经统计学处理有显著性差异 (P <0 .0 5) ;单药治疗显效时间 12 .2 8± 7.0 6d ,有效剂量 3± 1.3 7mg/ (kg·d) ,较添加组 3 3± 11.98d、6.78± 2 .0 4mg/ (kg·d)显效快、有效剂量小 ,经统计学处理有显著性差异 (P均 <0 .0 1)。结论 TPM治疗ADEE早期单药较添加效果好 。
Objective Study the ideal drug to treat age depen de nt epileptic ncephalopathy (ADEE) in earlier period. Methods fi fty-four patients with ADEE were studyed.21 cases used with single topiramate(T PM) as initial treatment and 27 cases used with TPM and antiepileptic drug(AEDs ) .Results Seizure was fully controlled in 11 patients with TPM m onotherapy and in 4 patients with TPM as adjunction.The differences was signif icant(P<0.05). The curative effect reached time (CERT) was 12.28±7.06 d in TPM monotherapy group with the effective dosage 3±1.37 mg/(kg·d). And the CER T was 33±11.98 d in TPM add-on group with the effective dosage 6.78±2.04 mg/(k g·d). The curative effect was reached earlier in TPM monotherapy group with les s dosage than that of TPM adjunction group.The differences were significant be tween two groups(P<0.01,respectively).Conclusions TPM mon otherapy was a better choice for treating ADEE in initial phase than as adju nctive strategy in advanced phase of ADEE.It is reasonable to select TPM as init ial administration in newly diagnosed ADEE.J Appl Clin Pediatr,2004,19(3):212-213
出处
《实用儿科临床杂志》
CAS
CSCD
北大核心
2004年第3期212-213,共2页
Journal of Applied Clinical Pediatrics
